Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Post translationally modified peptide"”.
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… resistant pathogens. Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products are genetically encoded peptide-derived secondary metabolites whose structures can be predicted based on gene sequence and identity of tailoring enzymes within the biosynthetic gene …
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Development Towards an Ethylene Sensing Artificial Metalloenzyme
… (MFT) is a ribosomally synthesized and post-translationally modified peptide (RiPP) hypothesized to function as a redox cofactor in bacteria, particularly the Mycobacteria genus, which includes M. tuberculosis. In order to further elucidate the function of MFT and its associated …
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Discovery and structural characterization of lanthipeptides from soil and rumen bacteria
As members of the ribosomally synthesized and post-translationally modified peptide natural products (RiPPs), lanthipeptides possess myriad structural diversity and potential for discovery using genome-guided approaches. Biological activities of interest embedded within lanthipeptide structures …
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Development of lanthipeptide engineering strategies
… source of therapeutic compounds. The lanthipeptides, members of the ribosomally synthesized and post-translationally modified peptide class of natural products, have potential applications ranging from clinical imaging to cystic fibrosis treatment. Additionally, many lanthipeptides possess …
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Investigation of the Lacticin 481 Synthetase and Its Substrate LctA in the Production of the Antibiotic Lacticin 481
Lantibiotics are ribosomally synthesized and post-translationally modified peptide antimicrobial agents produced by Gram-positive bacteria that contain thioether cross-links termed lanthionines. Lantibiotic biosynthesis begins with a precursor peptide (LanA) consisting of leader and propeptide …
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Biosynthetic engineering of plantazolicin natural products
… (PZN) is a ribosomally synthesized and post-translationally modified peptide (RiPP) natural product that exhibits extraordinarily narrow-spectrum antibacterial activity towards the causative agent of anthrax, Bacillus anthracis. During PZN biosynthesis, a cyclodehydratase catalyzes …
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New Insights into Mycofactocin Biosynthesis, Structure and Function
… is a putative ribosomally synthesized and post-translationally modified peptide (RiPP)-derived redox cofactor. Its biosynthesis is accomplished through the dedicated actions of the products of six conserved genes, <em>mftABCDEF</em>. The mycofactocin pathway is one of the most widely …
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Studies on the mechanism of action of the antimicrobial S-linked glycopeptide sublancin
… generating analogs. Ribosomally synthesized and post-translationally modified peptide (RiPP) natural products are a rapidly expanding class of compounds with antimicrobial activity. Sublancin is one of five members of the glycocin family of RiPPs, and contains an unusual S-linked glycosylation. …
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Investigation of lanthipeptides and their applications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-05-01
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Revealing the molecular details of azoline formation in ribosomal natural product biosynthesis
The thiazole/oxazole-modified microcins (TOMMs) are a recently grouped class of ribosomally synthesized and posttranslationally modified peptides. Encoded by many bacteria and archaea, these natural products occupy a large chemical and functional space and are linked by the presence of the …