Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Post‑antibiotic effect"”.
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Investigations of the postantibiotic effect and related antibacterial activity of meropenem.
This study was initiated to investigate the post antibiotic effect and related antibacterial activity of the carbapenem antibiotic, meropenem. The antibacterial activity of meropenem was determined by establishing minimum inhibitory and minimum bactericidal concentrations when tested against the …
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Model-Based Dose-Exposure-Response Assessment for Lead and Backup Spectinamide in a Mouse Model of Tuberculosis
… analysis was performed using non-linear mixed effect modeling to estimate pharmacokinetic parameters in healthy animals. The Bayesian principles were applied for reliable pharmacokinetic estimation in infected animals by using informed priors obtained from healthy animals. The individual …
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Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… resistance to the formally and currently used antibiotics. The Centers for Disease Control and Prevention (CDC) have listed multi-drug resistant N. gonorrhoeae as an urgent threat that promptly requires the development of novel therapeutic agents. Traditional drug discovery and development is a …
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PKPD-Model Based Preclinical Characterization of the Activity of Spectinamide 1599 Against Mycobacterial Subpopulations. and the Identification of Potential Partners for Combination Therapy
… MDR isolates, lack of cross resistance, long post antibiotic effect, and low toxicity potential. It also has a favorable pharmacokinetic profile and is primarily eliminated in the urine and thus has a low propensity for drug-drug interaction with other partner drugs. In addition, spectinamide …