Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 131 for “"Positron emission tomography (PET)"”.
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Compressive Sensing in Positron Emission Tomography (PET) Imaging
Positron emission tomography (PET) is a nuclear medicine functional imaging modality, applicable to several clinical problems, but especially in detecting the metabolic activity (as in cancer). PET scanners use multiple rings of gamma ray detectors that surround the patient. These scanners are …
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Microfluidic modules for pre-concentration of [¹⁸F]fluoride in positron emission tomography (PET) radiotracer synthesis
lPositron Emission Tomography (PET) is a non-invasive imaging method which enables to obtain both molecular and biochemical information of physiological processes in vivo, which means that PET imaging shows the chemical functioning of organs and tissues in a living subject. In recent years …
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Developing a selective sphingosine-1-phosphate-5 (s1p5) radiotracer to image oligodendrocytes using preclinical positron emission tomography (PET)
… (MRI). In this thesis we aimed to develop novel Positron Emission Tomography (PET) ligands to specifically bind to oligodendrocytes in the central nervous system in vivo. The ligands target the sphingosine-1-phosphate-5 (S1P5) receptor as a potential marker of oligodendrocyte function with PET. …
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Synthesis and evaluation of fluorine-18 labeled androgens as in vivo imaging agents for prostatic cancer using PET
… for in vivo imaging of prostatic cancer using positron emission tomography (PET), four pairs of 16$\beta$- and 16$\alpha$-fluoro androgens, as well as two 20-fluoro androgens have been synthesized. The fluorination was achieved mainly by nucleophilic fluoride displacement of a triflate or a …
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Quantitative multi-modal analysis of pediatric focal epilepsy
… resonance imaging (MRI), diffusion tensor MRI, positron emission tomography (PET), single-photon emission computerized tomography (SPECT) as well as EEG data to build patient-specific head models and to compute prior probability maps of epileptic hotspots for more accurate EEG source …
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System Solution for In-Beam Positron Emission Tomography Monitoring of Radiation Therapy
In-beam Positron Emission Tomography (PET) is a system for monitoring high precision radiation therapy which is in the most cases applied to the tumors near organs at risk. High quality and fast availability of in-beam PET images are, therefore, extremely important for successful verification of …
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Risk Factors, Mechanisms and Therapeuthic for Right Heart Failure Associated with Pulmonary Hypertension
… I employed small animal molecular imaging using positron emission tomography (PET) to non-invasively investigate these pathways. The PET imaging techniques employed in this thesis have the unique potential for translation to human studies, to further explore disease mechanisms.
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Multiple detector wireless FNIRS sensor to detect hemodynamic activity
… as functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomography (PET), Electroencephalography (EEG) and Event Related brain Potentials (ERP) have increased our understanding of brain functionality, however, the basic limitations of these technologies such as high cost of equipment, …
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
… To do so, we used the clinically relevant positron emission tomography (PET) imaging agent, <sup>89</sup>Zr-DFO-pertuzumab, in mouse models of human breast cancer. In the second part, we developed two imaging agents for ovarian cancer, <sup>89</sup>Zr-DFO-AR20.5 for PET and …
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Emotion, Depression, and Asymmetric Brain Function
… functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) studies have largely failed to identify specific brain regions showing this effect. This failure likely stems in part from the widespread use of inappropriate data analytic strategies. The present project used a …
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Investigations into a positron emission imaging algorithm
A positron emission imaging algorithm which makes use of the entire set of lines-of-response in list-mode form is presented. The algorithm parameterises the lines-of-response by a Cartesian mesh over the field-of-view of a Positron Emission Tomography (PET) scanner to find their density …
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The development of a simple process for producing medicinal diagnostic 18F agents for molecular imaging using positron-emission-tomography
… radiotracers for use as imaging agents in positron-emission-tomography (PET). The RLV strategy immobilises a precursor to the desired radiotracer on a solid support which is cleaved on exposure to [18F]-fluoride ion to give the 18F-labelled radiotracer in solution. The RLV methodology …
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Approaches for respiratory motion compensation in positron emission tomography imaging
… blur and inaccurate quantitation results in positron emission tomography (PET) imaging. Traditional gated acquisition approach corrects motion artifacts by generating a snapshot sequence. Each snapshot, however, is of poor image quality due to insufficient photon counts. This dissertation …
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The Development of Novel Platforms for the Imaging of Cancer by Positron Emission Tomography
… role of antibody-based imaging of cancer by positron emission tomography (PET) has expanded significantly in recent years and is poised to radically alter the way that cancer is diagnosed and treated. However, one hurdle that remains is the potentially harmful radiation dose that comes from …
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The development of positron imaging systems for applications in industrial process tomography
The diagnostic medical imaging technique of Positron Emission Tomography (PET) has been adapted at the University of Birmingham for use in imaging industrial processes. A particularly powerful technique, called Positron Emission Particle Tracking (PEPT) is used to study granular materials and fluid …
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New technique for radiolabelling tracer with 64CU for positron emission particles tracking (PEPT) experiments
Positron emission particle tracking (PEPT) is a non-invasive technique for studying the flow of particulate systems within industrial equipment. The technique tracks a tracer particle labelled with a positron emitting radionuclide moving within the field-of-view of a positron emission tomography …
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Solid-State NMR Characterization of a PET Ligand Binding Sites in AD Tau Fibrils
… around a study on the binding sites of a positron emission tomography (PET) ligand, PI-2620, to a recombinant tau construct that adopts the C-shaped AD fold. Using solid state NMR experiments in combination with other techniques such as Transmission Electron microscopy (TEM) as well as …
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Control and characterization of a cyclotron proton beam
… of Missouri Research Reactor (MURR) is used for positron emission tomography (PET) applications. Pharmaceutical radioisotopes are produced and delivered to local hospitals for cancer diagnosis and nuclear imaging. The proton beam's energy is 16.5 MeV and the diameter of the beam is approximately …
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Evaluation of room-temperature semiconductor detectors for ultrahigh resolution pet imaging
… semiconductor detector for ultrahigh resolution positron emission tomography (PET) imaging is presented. The approach is based on the use of a CdTe semiconductor detector. The detector is a 2mm thick cadmium telluride (CdTe) detector with a pixel pitch of 350μm x 350μm; it is bump bonded to an …
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Computer-assisted detection of lung cancer nudules in medical chest X-rays
… Magnetic Resonance Imaging (MRI), Computerized Tomography (CT) and Positron Emission Tomography (PET). However, the hardware instalment and operation costs of these systems remain considerably higher than x-ray systems. Conventional x-ray photography also has the advantage of producing an image …
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