Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Positron Emission Tomography (pet) Imaging"”.
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Compressive Sensing in Positron Emission Tomography (PET) Imaging
Positron emission tomography (PET) is a nuclear medicine functional imaging modality, applicable to several clinical problems, but especially in detecting the metabolic activity (as in cancer). PET scanners use multiple rings of gamma ray detectors that surround the patient. These scanners are …
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Leveraging Antibodies for Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Cancer
… explore the synthesis and use of antibody-based imaging agents in preclinical models of cancer. This work can be described as two-fold. In the first part, we investigated how the use of a glycans-specific bioconjugation strategy affects Fc gamma RI binding and why it results in improved <em>in …
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Approaches for respiratory motion compensation in positron emission tomography imaging
… blur and inaccurate quantitation results in positron emission tomography (PET) imaging. Traditional gated acquisition approach corrects motion artifacts by generating a snapshot sequence. Each snapshot, however, is of poor image quality due to insufficient photon counts. This dissertation …
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Evaluation of room-temperature semiconductor detectors for ultrahigh resolution pet imaging
… semiconductor detector for ultrahigh resolution positron emission tomography (PET) imaging is presented. The approach is based on the use of a CdTe semiconductor detector. The detector is a 2mm thick cadmium telluride (CdTe) detector with a pixel pitch of 350μm x 350μm; it is bump bonded to an …
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Development of nitrogen protecting groups and synthesis and complexation of bridged bis-tetraazamacrocycles
… for a variety of biomedical purposes including positron emission tomography (PET) imaging.</p><p>The N-allyl protecting group was also used to synthesize a cross-bridged bis-cyclen 31 that can now be further functionalized for a variety of biomedical purposes. Copper (II) and zinc (II) complexes …
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Vitamin B12 Bioconjugates In Pharmaceutical Design
… in in vivo tumor uptake? </p> <p>Goal: Conduct positron emission tomography (PET) imaging and biodistribution studies in mice bearing MDA-MB-453 breast cancer tumors using a new 89Zr-B12 conjugate.</p> <p>Q2: (Chapter 3) What is the uptake of systemically administered holo-intrinisic factor …
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Characterization of TSPO expression and radioligand-binding in the central nervous system and peripheral blood in neuroinflammatory disease
… Protein (TSPO) is a mitochondrial protein and positron emission tomography (PET)-imaging target that is highly upregulated in MS brain lesions and may potentially represent both an inflammatory biomarker and a therapeutic target for the monitoring and treatment of MS. However, its pathological …
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De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
… assessing their utility and effectiveness for positron emission tomography (PET) imaging of neurodegeneration. Three proteins were targeted: 1) colony stimulating factor-1 receptor (CSF-1R); 2) glycogen synthase kinase-3 (GSK-3); and 3) transactivation response DNA-binding protein with …
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The involvement of microglial activation in schizophrenia
… assess microglia activation in vivo, we obtained positron emission tomography (PET) imaging data from collaborators, who used a radiotracer to assess potential altered microglia activation in patients suffering from schizophrenia. Finally, as a proof of concept study, we attempted to validate …
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Biodistribution Studies of 64Cu-DOTA-Cetuximab after Intraperitoneal and Intravenous Injection in a Malignant Ascites Mouse Model of Human Gastric Carcinoma
… intravenous (i.v.) or i.p. injection. Positron emission tomography (PET) imaging and biodistribution studies were conducted at the indicated time points. In the bilateral SQ tumor model, the peak uptake of radiolabeled cetuximab in the NUGC-4 and MKN-45 tumors was detected at 24 h …
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Evaluation of yttrium-90 positron emission tomography dosimetry
… of <sup>90</sup>Y has been shown to allow for positron emission tomography (PET) imaging following radioembolization. This work explores the accuracy and limitation of <sup>90</sup>Y PET imaging due to the extremely low signal to noise (SNR) ratio associated with <sup>90</sup>Y and verifies the …
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Novel Network-Based Models for High-dimensional Data
… simulation studies, our method outperforms com peting techniques in terms of variable selection, parameter estimation, and outcome prediction. We applied this model to breast cancer clinical and RNA sequencing data from The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression Project …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
Imaging molecular techniques including PET, CT, MRI allow to detect and to monitor normal and pathological conditions non-invasively in clinic. The recent development of dedicated small animal instruments together to the availability of appropriate animal models of disease has allowed the use of …
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Development of multifunctional compounds for the modulation and detection of amyloid beta species
… used as potential therapeutic compounds for AD. Positron emission tomography (PET) is a functional imaging technique that can be used for the diagnosis of AD. Recently, several PET imaging agents have been approved by FDA and can be used to visualize amyloid plaques in AD patients. However, these …
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Development of amphiphilic compounds as therapeutic and diagnostic agents targeting amyloid aggregates for Alzheimer’s Disease
This Dissertation was approved for publication on 2023-07-12 at 15:07.