Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Positive modulator"”.
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MECHANISMS BY WHICH XRCC3 MEDIATES BREAST CANCER CELL INVASION VIA CYCLOPHILIN A
… This raises the question of whether XRCC3 is a positive modulator of invasion or whether overexpressed XRCC3 is trapped in non-functional complexes, resulting in a dominant negative effect. To address this we transiently downregulated XRCC3 in a triple-negative breast cell line model of …
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A study of Notch signalling in developmental angiogenesis
… thereby confirming its role as a negative and positive modulator of Notch and Wnt signalling, respectively. Mice null for Lymphoid enhancer factor 1 (Lef1) or deficient in endothelial Ctnnb1 also displayed increased vessel regression and decreased vessel density, suggesting a role of canonical …
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Pharmacological and Pharmacokinetic Studies of a K<sub>Ca</sub>2.2 Positive Allosteric Modulator
… channel rescued by a K<sub>Ca</sub>2.2 positive modulator. A positive allosteric modulator of K<sub>Ca</sub>2.2/K<sub>Ca</sub>2.3 channels (compound <strong>2q</strong>) has been developed, and a method for quantitating it in mouse plasma has been validated using FDA guidelines. The …
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Il trattamento neonatale con estradiolo modifica l'espressione e la funzione dei recettori GABAA e la sensibilità allo stress nel ratto adulto
… Given that allopregnanolone is a potent positive modulator of GABAA receptor (GABAAR) expression and function, it has been evaluated whether neonatal estradiol treatment affects, during adulthood, GABAAR expression and function in the hippocampus, an area that exhibits the two components, …
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Ion channel modulation during Chlamydia trachomatis development
… recruited to the inclusion. Correspondingly, the positive modulator of the heteromeric channel PIP2 did not colocalise with Kir6 at the inclusion. Analysis of K+ flux following siRNA-mediated knockdown of Kir6 in infected cells revealed Kir6 was essential for RB acquisition of K+ at the inclusion …