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Showing 1 to 8 of 8 for “"Position Effect Variegation"”.

  1. Role of JIL-1 chromosomal kinase in dosage compensation and position effect variegation in Drosophila melanogaster

    Lerach, Stephanie2004

    iastate Repository record

  2. The genetic and molecular analysis of the mfs(2)31 locus in Drosophila melanogaster : a novel suppressor of position-effect variegation

    Whitehead, Ian P.University of British Columbia1993

    Position-effect variegation (PEV) is the variable inactivation of a euchromatic gene which has been moved, by way of a chromosomal rearrangement, into a heterochromatic environment. The transcriptional repression at the variegating locus is thought to be a consequence of inappropriate packaging of …

    ubc Repository record

  3. Derepression of heterochromatin inactivation by induction of a nearby promoter in Drosophila melanogaster

    McNeill, Daniel Renick2019

    Position-effect variegation (PEV) describes the compaction of a euchromatic gene placed next to a region of heterochromatin. This compaction into heterochromatin in some instances results in a mosaic phenotype in Drosophila melanogaster. Since its discovery in the 1930's the phenomenon of PEV has …

    wvu Repository record

  4. Transcriptional targeting of lentiviral vectors to the erythroblastic progeny of hematopoietic stem cells

    Lotti, FrancescoThe Open University2003

    … HIV-derived lentiviral vectors are very effective in transducing rare, non-dividing stem cell populations without altering their long-term repopulation and differentiation capacity. We developed a strategy for transcriptional targeting' of lentiviral vectors based on replacing the viral …

    the-open-u Repository record

  5. The Mechanism Of Regulation Of Autosomal Heterochromatic Genes In drosophila Melanogaster Males By rox Rna And Msl Proteins

    Koya, Satya Kiran2014

    … Reduction of <i>roX</i> function suppresses position effect variegation (PEV), revealing functional alteration in heterochromatin. The effects of <i>roX</i> mutations on heterochromatic gene expression and PEV are limited to males. We proposed that <i>roX</i> and some MSL proteins have an …

    wayne-thes Repository record

  6. Silencing Through Heterochromatin Formation: The Role of Piwi in Transposon Targeting

    Wang, Hsiming2014

    … variegating pigmentation in the eyes, i.e. Position Effect Variegation: PEV). The PEV phenotype is known to be quite variable, and I have found that much of the variation has a genetic basis: Chap. 2). Using PEV reporter lines I have investigated a subtype of heterochromatin, the telomeric …

    wustl Repository record

  7. The role of Ultrabithorax negative autoregulation in Drosophila melanogaster

    Ranade, Vikram2013

    … of heterochromatin and ii) the expression of Position Effect Variegation reporters also changes when outcrossed to certain wild populations of D. melanogaster. Together, these results suggest that there are considerable fluctuations in the transcriptional landscape between different …

    columbia-diss Repository record

  8. Molekulare Analyse der differentiellen Funktionen von Linkerhiston Isoformen bei Caenorhabditis elegans.

    Jedrusik-Bode, Monika2012

    … beschrieben wurde, wurden auch in dem Telomer-Positionseffekt-Variegation-System der Hefen getestet. Es wurde herausgefunden, dass sie in diesem System funktionieren. Daraus kann man schließen, dass bestimmte molekulare Mechanismen zwischen den Hefen und C. elegans übereinstimmen.Im Rahmen …

    goettingen Repository record