Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Porous scaffold"”.
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FABRICATION AND CHARACTERIZATION OF CELL-LADEN 3D PRINTED HYBRID SCAFFOLDS FOR ESOPHAGEAL TISSUE REPAIR
… are hardly used to achieve a suitable scaffold for esophageal TE. In this study, a hybrid porous scaffold consisting a layer of electrohydrodynamic jet printed (E-jetted) polycaprolactone (PCL) / Pluronic F127 (F127) fiber mesh, and a layer of electrohydrodynamic sprayed (E-sparyed) …
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Modeling cell proliferation in a perfusion tissue engineering bioreactor
… place in a bioreactor in which a cell seeded porous scaffold is placed, and the scaffold experiences a perfused flow of a nutrient-rich culture medium. The goal of the model is to assist experimentalists in evaluation of different parameter scenarios as the time needed to simulate an …
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Potential commercialization of a collagen-GAG scaffold for liver regeneration
The potential for commercializing a scaffold made of collagen and glycosaminoglycan to help regenerate cirrhotic liver was analyzed and a business plan and model were created. Using a lypholization technique, a bulk-sized and highly porous scaffold is created. It is then inserted into the hole …
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Image-Based Quantification and Coupled PNM-FEM of Architecture, Deformation, and Fluid Dynamics in Biological Porous Media Under Mechanical Loading
… tissues. The extracellular matrix (ECM), a porous scaffold filled with fluid, governs key cellular functions. The composition and architectural characteristics of the ECM, such as porosity, pore connectivity, pore size, and tortuosity, vary with tissue type and states, and these parameters …
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Mask Projection Microstereolithography 3D Printing of Gelatin Methacrylate
… GelMA resin was tested with µSL to create a porous scaffold with a height and print time that has not been displayed in the literature before for a scaffold of this size. The resin consists of GelMA, deionized water, lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP, photoinitiator), and …
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Cell-mediated contraction & induced regeneration of the injured peripheral nerve
… library of type I collagen tubular scaffolds with identical chemical composition and pore size, and varying degradation rate was used to evaluate the ability of a porous scaffold to block MFB contraction after injury in a demanding model of peripheral nerve regeneration in the adult …
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Quantitative analysis of 2D and 3D models for epidermal growth factor receptor-dependent cell migration in the context of the extracellular microenvironment
… Lastly, we quantified fibroblast migration in a porous scaffold of varying pore sizes and stiffness to model contact-guided quasi-3D migration. We surprisingly found that the micro-architecture of guidance structures alone influenced cell speed. Therefore, the combination of biologically relevant …
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Investigation into the development of a gelatin-based biocomposite for wound-management
… in contact with the wound bed, was a gelatin scaffold of uniform porosity produced through an optimised gas foaming method. In this part of the research, in addition to optimising the gas foaming process parameters, a comprehensive comparison between applying four different crosslinking agents …
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A multiscale mechanobiological investigation of scaffold designs for bone tissue engineering
… bone tissue engineering to develop biomaterial scaffolds as bone graft substitutes that can meet or exceed the performance of autografts. A critical but understudied aspect of that development is advancing understanding of how skeletal cells respond to the multitude of cues - mechanical and …
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A Novel Biostable 3D Porous Collagen Scaffold for Implantable Biosensor
… of implantable glucose sensors, a new 3D porous and bio-stable collagen scaffold has been developed to improve the biocompatibility of implantable glucose sensors. The novel collagen scaffold was crosslinked using nordihydroguaiaretic acid (NDGA) to enhance biostability. NDGA-treated …
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A Novel Biomimetic Scaffold for Guided Tissue Regeneration of the Pulp - Dentin Complex
… been addressed. We have proposed a biomimetic scaffold to facilitate early stage stratification of these different tissues and allow recapitulation of their interface. Tissue engineering principles and biomaterial processing techniques were used simultaneously to encourage dental pulp stem …
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Materials and Nanostructured Coatings for Soft Tissue Regeneration
… with the use of polymeric substrates (myocardial scaffolds or heart patches) that can reduce cell loss and potentially prevent remodeling and fibrotic processes. In in vivo MTE strategies, scaffolds should be capable to recruit cardiac progenitor and differentiated cells which are present in the …