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Showing 1 to 3 of 3 for “"Porcn"”.
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The Role of the X-chromosomal Porcupine Homolog Gene in Mouse Development
… tissue homeostasis in adults. The X-chromosomal Porcn gene encodes a membrane-bound O-acyl transferase that is required for the acylation of all 19 WNT ligands encoded in the mammalian genome. Non-acylated WNTs fail to be secreted from the producing cell and thus do not activate downstream …
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Structural Investigations of Porcupine and Dispatched-1 in Wnt and Hedgehog Morphogen Biogenesis
… membrane-bound O-acyltransferase Porcupine (PORCN) is indispensable for Wnt binding to its receptor Frizzled, which triggers signaling. I report four cryo-EM structures of human PORCN: the complex with its substrate palmitoleoyl-coenzyme A, the complex with the PORCN inhibitor LGK974, the …
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Mechanisms of Genome Buffering and Cell Fate Coordination in Adult Tissue Homeostasis
… Wnt proteins by the acyltransferase Porcupine (Porcn) is crucial for secretory pathway exiting. Using chemically based approaches, I have demonstrated that Porcn active site features conserved across animals enforce ω-7 cis fatty acylation of Wnt proteins. Deviant acylation of a Wnt protein …