Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)"”.
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Development of subunit vaccines against porcine reproductive and respiratory syndrome virus (PRRSV)
Since emerging in Europe and the US, PRRS has spread globally and become the most significant infectious disease currently devastating the swine industry. In the US alone, the economic losses caused by this disease amount to more than 560 million US dollars every year. Modified-live PRRSV vaccines …
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Reverse Genetics-based Approaches to Attenuate Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
Porcine reproductive and respiratory syndrome virus (PRRSV) is arguably the most economically-important swine pathogen. As the emergences of novel virulent strains of PRRSV continue to occur worldwide, rapid vaccine development is the key for effective control of ongoing PRRSV outbreaks. With the …
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Molecular Mechanisms of Host Responses to Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection
Porcine reproductive and respiratory syndrome virus (PRRSV) is arguably the most economically devastating pathogen affecting the global swine industry. Since the emergence of the virus in the late 1980s, vaccination strategies aimed to control the virus have not been very effective. Current …
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Surveillance in contemporary swine herds - the case of porcine reproductive and respiratory syndrome virus (PRRSV)
… means to generate information on the presence and/or distribution of pathogens in animal populations. Fulfillment of this function is ultimately dependent on the program's ability to collect, test, aggregate, and analyze data from individual samples. The problem addressed in this dissertation …
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Purification of the major envelope protein GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) from native virions
Porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of a pandemic that has been devastating the U.S. and global swine industry for more than twenty years. PRRSV vaccine development is challenging due to virus heterogeneity. Evidence indicates that the major envelope protein, …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine epidemic diarrhea virus (PEDV) are two of the most prevalent swine pathogens that have impacted the global swine industry for decades. Both are RNA viruses with increasing heterogeneity over the years, making a vaccine solution …
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Molecular characterization of the major envelope protein of porcine reproductive and respiratory syndrome virus (PRRSV) and evaluation of its use for a diagnostic assay, vaccine development, and the examination of quasispecies evolution
Porcine reproductive and respiratory syndrome (PRRS) is a viral disease that has devastated the global swine industry since the mid 1980s. Although modified live vaccines (MLVs) are typically used for the prevention of clinical disease, they are not always fully effective. Additionally, acute PRRS …
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Immune Response of Swine to Porcine Reproductive and Respiratory Syndrome Virus: Laboratory and Field Studies
Porcine reproductive and respiratory syndrome virus (PRRSv) is an arterivirus that has had a significant economic impact on the pork industry in the past few decades. Our studies have focused on three major issues that concern alleviation of this problem. These include utilizing contact exposure to …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogenics affecting swine industry worldwide. PRRSV is a single-stranded and positive sense RNA virus that belongs to the family of the Arteriviridae (genus Arterivirus). PRRSV has a restricted …
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Mixed Strain Identification of Porcine Reproductive and Respiratory Syndrome Virus in Multiplexed Samples using Nanopore Sequencing
For over thirty years, Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) has been a major contributor to morbidity and mortality in the commercial swine industry across the globe. This highly mutagenic RNA virus causes significant economic losses wherever it is prevalent, leading to $664 …
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Studies on the interaction between porcine reproductive and respiratory syndrome virus and its natural host cell
Porcine reproductive and respiratory syndrome virus (PRRSV), an arterivirus, causes a costly global disease of swine. PRRSV infects their alveolar macrophages (AMΦ) resulting in an interstitial pneumonia. The ability of PRRSV to modulate the production of interferon (IFN)a and tumor necrosis factor …
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Effects of Heat Stress and Porcine Reproductive and Respiratory Syndrome Virus on Metabolism
Heat stress and immune challenge are costly issues to the swine industry causing significant loss in production and health including reduced efficiency in muscle accretion and energy utilization. Alterations to metabolism and immune response may participate in these shortcomings. The study …
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Development of a Fluorescence Microsphere Immunoassay for Detection of PRRSV Infection Using Oral Fluid Samples as an Alternative to Serum-based Assays
<p>Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be one of the most devastating diseases in the swine industry throughout the world. PRRSV has caused the swine industry more than $600 million a year. PRRSV causes late term abortions, infertility, and severe respiratory …
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Behavioral analysis of piglets exposed to a second immune challenge following maternal immune activation
… effects of maternal immune activation (MIA) and a second immune challenge later in life on pig behavior have not been studied. Deciphering these effects is particularly relevant in diseases that can have pronounced effects during gestation, such as porcine reproductive and respiratory …
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The effects of virus-induced maternal inflammation on methylation patterns in skeletal muscle
… abnormalities. In pigs, maternal infection with porcine reproductive and respiratory syndrome virus (PRRSV) increases inflammatory cytokines in the offspring, influences myogenic gene expression, and decreases total muscle fiber number. Disease and inflammation during gestation influences DNA …
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Intranasal Immunization of Pigs with Porcine Reproductive and Respiratory Syndrome Virus like Particles Plus 2’, 3’ –cGamp Vaccigrade™ Adjuvant Exacerbates Viremia After Virus Challenge
<p>Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically devastating virus that causes a persistent infection and spreads quickly. The virus causes abortions in sows and respiratory diseases in young piglets. Current PRRSV vaccines appear to provide limited …
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Porcine circovirus associated disease: Modulation of the host immune response to PCV2 and PRRSV by regulatory T cells
Porcine circovirus associated disease (PCVAD) is currently one of the most economically important diseases facing the global swine industry. Porcine circovirus type 2 (PCV2) is the primary and essential causative agent of PCVAD, but development of clinical disease typically requires co-infection …
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Identification and characterization of a novel structural protein of porcine reproductive and respiratory syndrome virus, the replicase nonstructural protein 2
<p>Porcine reproductive and respiratory syndrome virus (PRRSV) is a rapidly mutating pathogen eliciting respiratory and reproductive disease of high economic consequence. The PRRSV non-structural protein 2 (nsp2) is a large multifunctional protein encoded by the most genetically diverse region of …
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Novel approaches to enhance the protective immune responses of vaccines against Porcine Reproductive and Respiratory Syndrome Virus
Since late 1980s, porcine reproductive and respiratory syndrome virus (PRRSV) has emerged as the most economically important swine pathogen affecting pig industries worldwide. Vaccination is the principal means that have been used for prevention of PRRSV infection. However, the currently available …
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Effects of variation in N-linked glycosylation site on antibody mediated neutralization in PRRSV
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a 15Kb enveloped positive-sense, single stranded RNA virus. More than two decades after the emergence of PRRSV, much is known about the viral genome, spread, and pathogenesis of the disease but our knowledge of the protective immune …
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