Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Population Stratification"”.
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Statistical methods for genetics and genomics studies
… quality is available. Genetics study : although population-based association mapping may be subject to the bias caused by population stratification, alternative methods that are robust to population stratification such as family-based linkage analysis have lower mapping resolution. In this …
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The Association of Single Nucleotide Polymorphisms (SNPs) in the Nitric Oxide Synthase 1 Adaptor Protein Gene (NOS1AP) and the QT Interval Duration Across Race/Ethnicity in Adults Without Clinical Cardiovascular Disease
… has been replicated in predominantly Caucasian populations. The MESA study provides an opportunity to study single nucleotide polymorphisms (SNPs) in NOS1AP for association with QT interval in an ethnically diverse cohort. Methods: Twenty-eight tagging SNPs, starting in the first intron and …
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Fine mapping studies of quantitative trait loci for baseline platelet count in mice and humans
… genetic similarity matrix index to correct for population stratification. The results from this in-silico association were then correlated with expression array data from parental samples and five genes were prioritised for more detailed analysis by resequencing. Two potential variants in these …
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Novel Algorithms and Methodology to Help Unravel Secrets that Next Generation Sequencing Data Can Tell
… second part we focus on the problem of inferring population stratification between individuals in a dataset due to reproductive isolation. While powerful methods for doing this have been proposed in the literature, they tend to struggle when faced with the sheer volume of data that comes with NGS. …
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Association Analyses of Estrogen Receptor a Gene Polymorphisms with Bone Geometric Property at The Femoral Neck in Caucasian Nuclear Families
… a family based association approach robust to population stratification was employed for analyses. Evidence of within-family association between SNP4 (rsl801132) and ED was detected in single locus analyses (P = 0.008) and verified in haplotype analyses (P = 0.034). The association was …
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Computational methods for genomic variant calling and analysis
… associations that may have been influenced by population stratification and a confounding effect of age. Chapter Three reports a comparison of genotyping-by-sequencing (GBS) analysis methods on plant data. As a reduced-representation sequencing method to identify genetic variants and quickly …
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Pharmacogenomics and pharmacokinetics of dolutegravir and tenofovir in Southern Africans living with HIV
… and tenofovir concentrations and developed population pharmacokinetic models for dolutegravir and tenofovir using non-linear mixed-effects modelling. Genome-wide genotyping followed by imputation was performed. Linear regression models examined associations between genetic polymorphisms and …
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Studies of aldosterone renin ratio and genetic variation at the CYP11B1/CYP11B2 locus in human essential hypertension
… locus is studied in several large population samples. Since minor changes in renin measurement may lead to significant changes in the ARR, an evaluation of methods to measure it in population studies was of fundamental importance. In Chapter 3, the performance of a novel automated …