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Showing 1 to 6 of 6 for “"Poorly water soluble compounds"”.
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Mechanisms of polymer adsorption in nanoparticle stabilization for poorly water soluble compounds
… were prepared by wet milling of drug with water as medium and polymers as stabilizers. Block copolymers were evaluated based on varying the hydrophobic and hydrophilic amounts, polymer concentration, and polymer affinity differences onto the nanoparticle surface. Specifically, block …
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Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
… of this strategy. Recently, polyphenolic compounds such as curcumin (CUR) and resveratrol (RES) are shown to have synergistic antioxidant, chemo-preventive, chondroprotective, and anticancer activity. However, their poor aqueous solubility limits their oral application. The purpose of this …
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Solubility Enhancement and Precipitation Inhibition of Poorly Water Soluble Compounds Utilizing Hot Melt Extrusion Technology
… the miscibility and solubility of the model compounds within Soluplus® , of which felodipine demonstrated higher solubility when compared to ketoconazole (14% vs 4.3% w/w) at room temperature (298K). Moreover, the solubility parameters of FEL, KTZ and SOL were calculated as 21.76, 26.51 and …
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DEVELOPMENT OF SUPERSATURATED MATRIX SYSTEMS FOR POORLY WATER-SOLUBLE COMPOUNDS BASED ON SPRAY-DRIED SOLID DISPERSIONS
… controlled release (CR) matrix system for poorly water-soluble drug in order to enhance its solubility and dissolution rate while maintaining the stability of the supersaturated state during and after dissolution. Two types of polymeric carriers, namely hydroxypropyl methylcellulose acetate …
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Solubility enhancement, mechanical properties and taste masking of poorly water soluble compounds by optimizing hot melt extrusion processing
… the use of this route for the delivery of poorly soluble actives. Conventional delivery systems used for oral drug delivery are solid dosage forms including capsules filled with milled material, tablets, and pellets. Current research focusing on actives with low aqueous solubility requires …
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The effect of additives on the molecular mobility, physical stability and dissolution of amorphous solid dispersions
… avenue for improving the oral bioavailability of poorly water-soluble compounds. However, crystallization of the amorphous phase during storage or dissolution could negate the solubility advantage. The objectives were to (i) develop an accelerated testing method for predicting the solid-state …