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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Poorly soluble drugs"”.
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Novel Biomimetic Polymeric Nanoconjugates as Drug Delivery Carriers for Poorly Soluble Drugs
… to increase the dissolution rate of the poorly soluble drugs. This work focuses on the formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to improve its physical and dissolution characteristics without the use of toxic organic …
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… used in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray dried composites …
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Solid Dispersions in Medium-Insoluble Hydrogels for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Formulating poorly water-soluble drugs into Amorphous Solid Dispersions (ASDs) based on medium-insoluble hydrogels is an emerging approach showing promise for tackling solubility related oral bioavailability problems. However, critical parameters important to the design of these ASDs have not been …
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Drug-cyclodextrin complexes: an approach to enhance the solubility and dissolution properties of poorly soluble drugs
… promote inclusion complexation between different drugs and cyclodextrins (econazole and α-cyclodextrin; indomethacin and methyl-β-cyclodextrin; olanzapine and methyl-β-cyclodextrin; flurbiprofen and methyl-β-cyclodextrin) in order to enhance the apparent solubility and dissolution properties of …
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A study of the mechanisms of milling-induced enhancement of solubility and dissolution rate of poorly soluble drugs
… the solubility and/or dissolution rate of poorly soluble drugs. There are broadly two aims for this project. The first was to develop an understanding of how individual and combination of techniques may be used to explore the impact of milling on particle characteristics (including phase …
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Improving the solubility and dissolution of poorly soluble drugs by salt formation and the consequent effect on mechanical properties
… and dissolution rate. Four carboxylic acid drugs were selected, which were flurbiprofen, etodolac, ibuprofen and gemfibrozil. The drugs were chosen because they are weak acids with poor aqueous solubility and should readily form salts. The counterions used for salt formation were: …
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Development Of Novel Deep Eutectic Solvents For Optimization And Characterization, Involving Bio Extraction And Delivery Of Drugs With Poor Solubility
… applications and enhance the solubility of poorly aqueous soluble drugs due to their lipophilic nature, considering this property of DES, solubility of several poorly soluble drugs was performed and quercetin, clofazimine had shown increased solubility in these solvents. DES solvents as …
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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… for size reduction to increase surface area of poorly soluble Active Pharmaceutical Ingredient’s (API). This size reduction improves the dissolution rate and permeability thereby increasing the bioavailability for hydrophobic API’s.</p> <p>Tablets and capsules are the most marketed and easy to …
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… was synthesized and characterized for releasing poorly soluble drugs as an injectable depot, a photo-crosslinked implantable matrix, temporarily stable nanodroplets and stable nanogels. Second, two acid-labile biodegradable liquid polymers were investigated for pH-responsive intracellular …
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In vitro and in silico profiling to assist pharmaceutical development
… order to find the appropriate formulation. For drugs intended to be administered orally water-solubility is a an essential requirement. The development of high-throughput screening and combinatorial chemistry gave a rapid access to a lot of potential drug candidates but as a consequence led to …
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Clarithromycin nanocrystals for high-dose inhalation
… approach to deliver clarithromycin locally. Poorly soluble clarithromycin (BCS II) was converted to nanocrystals by wet media milling. Spray-dried hollow microparticles, so called "Trojan particles", in which nanocrystals are incorporated in a matrix shell are designed for deep-lung …
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Synthesis of Polysaccharide-based Biomaterials for Drug Delivery
… carriers. ASDs are polymeric systems to disperse poorly soluble drugs amorphously and enhance permeation from the gastrointestinal tract (GI tract) to the bloodstream. We synthesized potentially zwitterionic cellulose derivatives by reductive amination of Ox-HPC with ω-aminoalkanoic acids and …
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Mechanistic studies to evaluate the targeting specificity of novel RGD Micelles to the αVβ3 integrin receptor
… specific ity to tumor cells, physically entrap poorly soluble drugs, and deliver these cytotoxic agents directly to the tumor site. One approach to nanosystem drug delivery is with the use of peptide amphiphiles (PAs) that are conjugated with the Arginine-Glycine-Aspartic Acid (RGD) motif to …
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Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… molecular interaction in drug-polymer systems of poorly soluble drugs and correlate it with the performance of prepared or reported SDs (solid dispersions). Crystallization tendencies of five different drugs [i.e. Curcumin (CUR), indomethacin (IND), flutaminde (FLU), dipyridamole (DIP), …
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Computational prediction of enhanced solubility of poorly aqueous soluble drugs prepared by hot melt method
… designed new chemical entities. Solubility of poorly soluble drugs is enhanced by physical and chemical modifications of drug. Shake flask method is the most commonly used experimental method to determine solubility. However, this method has several limitations. A single solubility experiment …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
Increasing emergence of drugs with poor solubility poses significant challenges for the pharmaceutical industry. A variety of techniques can be used to help improve the solubility profile of these difficult-to-deliver compounds. Intradermal delivery of poorly soluble drugs involves the delivery of …
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Design and Synthesis of Complex and Fluorescent Labeled Cellulose-Based Derivatives for Orally Administered Drug Delivery Systems
… vehicles that can solubilize and stabilize poorly soluble drugs by increasing the time that it takes for drugs to crystallize, thereby allowing higher drug concentrations and providing increased bioavailability. However, most commercially available cellulose derivatives were not specifically …
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Development of Amorphous Ternary Solid Dispersions of a Novel Anti-Tubercular Indole-2-Carboxamide Derivative with Curcumin/Clofazimine for Tuberculosis Treatment
… enhance the aqueous solubility of incorporated poorly soluble drugs. A highly potent novel anti-tubercular drug (i.e., Indole-2-carboxamide derivative (North 2)) was combined with an antioxidant (i.e., curcumin) and an anti-tubercular drug, clofazimine. Binary and ternary amorphous dispersions …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… share, has been considered for the delivery of poorly soluble actives. The use of appropriate carrier matrices (polymers) and excipients help in incorporating these drugs and developing a dosage form/drug delivery system with desired properties. The oral delivery systems are most popular, …
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Inorganic nanoparticles for applications in biomedical sciences
… offers several advantages like delivery of poorly soluble drugs, better bioavailability, targeted delivery and extended release of drugs. In this work, we demonstrated the formulation and methods of use for three different nanocarriers. 1) 166Ho iron garnet nanoparticle-containing bandages …
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