Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Poorly soluble"”.
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Lipid & surfactant based systems for improved delivery of poorly soluble APIs
<p>A large number of pharmaceutical compounds belong to class II and IV of biopharmaceutical classification of drug (BCS). Class II compounds are limited by their poor aqueous solubility, while class IV compounds suffer from poor solubility and permeability. This translates to poor absorption and …
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Novel formulations of a poorly soluble drug using the extrusion process.
… been investigated to improve the properties of poorly soluble thermolabile drugs; polymeric solid dispersions and solid state polymorphic transformation. HME is a solvent free, continuous and readily scalable technique which is increasingly being considered as a viable alternative to …
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Novel Biomimetic Polymeric Nanoconjugates as Drug Delivery Carriers for Poorly Soluble Drugs
… to increase the dissolution rate of the poorly soluble drugs. This work focuses on the formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to improve its physical and dissolution characteristics without the use of toxic organic …
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Preparation of amorphous forms to increase the solubility of poorly soluble drugs using spray drying
… used in enhancing the aqueous solubility of poorly soluble compounds. In this study, the mechanism of solubility enhancement was characterized using three model drugs-naproxen, ketoprofen and furosemide. Physical mixtures of the model drug with polyvinylpyrrolidine and spray dried composites …
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Development of novel polymeric microneedle systems for long-acting intradermal delivery of poorly soluble compounds
… compounds. Intradermal delivery of poorly soluble drugs involves the delivery of drugs into the skin to exert localised effects. However, relatively few drugs possess the necessary properties to passively traverse the skin and remain in the skin in a high level and long-acting way. …
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Continuous manufacture of enabling formulations for a poorly soluble compound using hot melt extrusion technology
Over the past few decades, hot melt extrusion has emerged as a tremendously useful and versatile technology within pharmaceutical research and development. As a well-established technique in the production of oral solid dosage formulations, its operating capacity has the capability to address …
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Solid Dispersions in Medium-Insoluble Hydrogels for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs
Formulating poorly water-soluble drugs into Amorphous Solid Dispersions (ASDs) based on medium-insoluble hydrogels is an emerging approach showing promise for tackling solubility related oral bioavailability problems. However, critical parameters important to the design of these ASDs have not been …
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Drug-cyclodextrin complexes: an approach to enhance the solubility and dissolution properties of poorly soluble drugs
The main objective of this study was to investigate different manufacturing processes claimed to promote inclusion complexation between different drugs and cyclodextrins (econazole and α-cyclodextrin; indomethacin and methyl-β-cyclodextrin; olanzapine and methyl-β-cyclodextrin; flurbiprofen and …
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A study of the mechanisms of milling-induced enhancement of solubility and dissolution rate of poorly soluble drugs
… the solubility and/or dissolution rate of poorly soluble drugs. There are broadly two aims for this project. The first was to develop an understanding of how individual and combination of techniques may be used to explore the impact of milling on particle characteristics (including phase …
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Improving the solubility and dissolution of poorly soluble drugs by salt formation and the consequent effect on mechanical properties
The bioavailability of BCS II compounds may be improved by an enhanced solubility and dissolution rate. Four carboxylic acid drugs were selected, which were flurbiprofen, etodolac, ibuprofen and gemfibrozil. The drugs were chosen because they are weak acids with poor aqueous solubility and should …
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The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development.
… properties of HFA propellants are however poorly understood and their capacity for solubilising inhaled pharmaceutical products (IPPs) and excipients used historically in CFCs differ significantly. There is therefore a drive to establish methodologies to study these systems in-situ and post …
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Predicting aqueous solubility of pharmaceutical agents by solid dispersion prepared by solvent evaporation method
… a desirable increase in the solubility of a poorly-soluble compound, a good understanding of the molecular descriptors influencing the enhancement of solubility is essential. Therefore, the major research objective was to determine the descriptors which significantly influence the solubility …
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… was synthesized and characterized for releasing poorly soluble drugs as an injectable depot, a photo-crosslinked implantable matrix, temporarily stable nanodroplets and stable nanogels. Second, two acid-labile biodegradable liquid polymers were investigated for pH-responsive intracellular …
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The development of PVP-based solid dispersions using hot melt extrusion for the preparation of immediate release formulations
Bioavailability and clinical effectiveness of a poorly soluble drug can be highly affected by its formulation design. In this respect, research on solid dispersion of hydrophilic carrier has commenced a decade ago to resolve the problem of poorly soluble drug. However, the availability of solid …
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Clarithromycin nanocrystals for high-dose inhalation
… approach to deliver clarithromycin locally. Poorly soluble clarithromycin (BCS II) was converted to nanocrystals by wet media milling. Spray-dried hollow microparticles, so called "Trojan particles", in which nanocrystals are incorporated in a matrix shell are designed for deep-lung …
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Development Of Novel Deep Eutectic Solvents For Optimization And Characterization, Involving Bio Extraction And Delivery Of Drugs With Poor Solubility
… applications and enhance the solubility of poorly aqueous soluble drugs due to their lipophilic nature, considering this property of DES, solubility of several poorly soluble drugs was performed and quercetin, clofazimine had shown increased solubility in these solvents. DES solvents as …
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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… for size reduction to increase surface area of poorly soluble Active Pharmaceutical Ingredient’s (API). This size reduction improves the dissolution rate and permeability thereby increasing the bioavailability for hydrophobic API’s.</p> <p>Tablets and capsules are the most marketed and easy to …
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COMPLEX FORMATION BY ALPHA-LACTALBUMIN AND POLYSACCHARIDE COPOLYMERS
… and pharmaceuticals to improve the dispersion of poorly-soluble ingredients or modify their bioaccessibility within the body. As a delivery system for medical- and health-relevant bioactive components, surfactant micelles have potential toxicity due to the disruption of cell membranes and …
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Preparation and solid state properties of cyclodextrin complexes of selected drug molecules
… number of pharmaceutically important drugs are poorly soluble in water. This study focuses on the 'smart' molecule that can enhance the solubility and hence increase the bioavailability of these drugs. This molecule is a cyclodextrin and is known to form inclusion compounds with various drug …
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