Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 735 for “"Pooled"”.
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Computational methods for high-throughput pooled genetic experiments
… in order to detect nonrandom associations in pooled data, including a novel approach based on hidden Markov models that optimally shares data across genomic locations. The methods are applied to new and existing datasets and improve on the resolution of published methods, frequently obtaining …
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Image-based pooled genetic screens for complex cellular phenotypes
… scalable functional genomics approaches such as pooled CRISPR screening, the cellular phenotypes that can be linked to gene function in a pooled screen have been restricted to measurement by sequencing, and are often a step removed from the biological process of interest. In contrast, microscopy …
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Reducing Provincial Drug Plan Costs Through Regional Pooled-Purchasing Agreements
Canada’s provincial health ministries are facing rising provincial drug plan costs that can be attributed to rising medication costs and increasing drug plan claims. Provinces currently employ a collection of policy tools that have not proven to be effective in reducing the cost of these essential …
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An Agent-based Simulation Tool for Evaluating Pooled Queue Performance at Marine Container Terminals
… system with two different queuing strategies, a pooled queue and non-pooled queues, since analytical solutions are not capable of capturing vehicle movements within the queue. Using a car following model, a realistic representation of how vehicles move within the queue is captured. The developed …
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Optimal Risk-based Pooled Testing in Public Health Screening, with Equity and Robustness Considerations
Group (pooled) testing, i.e., testing multiple subjects simultaneously with a single test, is essential for classifying a large population of subjects as positive or negative for a binary characteristic (e.g., presence of a disease, genetic disorder, or a product defect). While group testing is …
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COFFEE AND TEA CONSUMPTION AND GASTRIC CANCER: A POOLED ANALYSIS IN AN INTERNATIONAL CONSORTIUM OF EPIDEMIOLOGICAL STUDIES.
… with gastric cancer risk, individual-participant pooled analyses in a unique global consortium of epidemiological studies on gastric cancer - the Stomach cancer Pooling (StoP) project- were carried out. The StoP project included thirty case-control (CC) studies and five nested case-control within …
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Financial Transfer and Its Impact on the Level of Democracy: A Pooled Cross-Sectional Time Series Model.
This dissertation is a pooled time series, cross-sectional, quantitative study of the impact of international financial transfer on the level of democracy. The study covers 174 developed and developing countries from 1976 through 1994. Through evaluating the democracy and democratization literature …
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Expanding Access to Novel Antibacterial Therapeutics in Low- and Middle-Income Countries: Leveraging Donor-Funded Pooled Procurement
… necessary to leverage an existing donor-funded pooled procurement strategy to expand its scope to include novel antibacterial therapeutics, with the goal of expanding access to these products in LMICs. Market access expansion would bring new products to patients where they are needed most while …
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Uncovering Markers for Honey Production and Defensive Behaviour Using Pooled Genome-Wide Data with the Honeybee (Apis Mellifera)
The honeybee (Apis mellifera) has been an important insect for both the study of social insect behaviour and agriculture. Honey production and defensive behaviour are honeybees two notable and economically valuable traits. Here we perform a genome-wide association study on 925 honeybee colonies …
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Evaluating pooled testing designs in community and healthcare settings for infectious disease management and in particular for epidemics
… available. Given a limited testing capacity, pooled testing (a method that involves combining samples taken from multiple individuals and analysing this with a single diagnostic test) has been suggested to reduce the average number of tests needed to identify infected individuals. Despite …
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Prevalence and Predictors of Unintended Births in Low and Middle-Income Countries: A Pooled Analysis of 27 Nationally Representative Surveys
<p>Introduction</p> <p>Rates of unintended births (UIBs) are disproportionately high in low- and middle-income countries (LMICs) where the capacity to provide care to unexpected mothers and their offspring is often lagging. To decrease the prevalence of UIBs and their negative impacts on children, …
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Economic Development, Social Dislocation and Political Turmoil in Sub-Saharan Africa: A Pooled Time-Series Analysis and a Test of Causality
… and political turmoil. This study employs pooled cross-sectional time-series and seemingly unrelated regression analyses, as well as Granger-causality, to examine the hypothesized relationships and causality in 24 Sub-Saharan African countries from 1971 to 1995. The results confirm the …
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Surveillance and improved control of American foulbrood in Saskatchewan honey bees through the detection of Paenibacillus larvae spores in pooled, extracted honey
… of spore detection in conveniently collected, pooled, extracted honey to determine AFB risk at a yard or operation level within antibiotic-reliant apiculture. Large-scale, commercial honey bee operations in Saskatchewan, Canada, with a history of antimicrobial use and recent outbreaks of AFB …
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Pooled resources: an experimental investigation of salt production and pottery manufacture within the LIA and Romano-British landscape of Poole Harbour, Dorset.
This paper explores links between Late Iron Age and Romano-British industries, around Poole Harbour, Dorset. Focusing on two major economic activities in the production of salt and a major pottery industry, South East Dorset Black Burnished Ware 1 (SEDBB1). Excavation has revealed evidence for a …
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Influence of Feeding Pooled Colostrum or Colostrum Replacement on IgG Levels and Evaluation of Animal Plasma as a Milk Replacer Protein Source
Newborn Holstein (n = 48) and Jersey (n = 30) calves were studied to compare the absorption of immunoglobulin G (IgG) from maternal colostrum (n = 39) or a colostrum replacement product derived from bovine serum (n = 39). Calves were also fed milk replacer with (n = 38) or without (n = 40) animal …
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KRAS Codon 12 and Codon 13 Mutations in Relation to Overall Survival among Colorectal Cancer Patients: A Systematic Review and Meta-Analysis
… Random-effects models were employed to quantify pooled association estimates and to investigate heterogeneity. Meta-regression was performed to examine sources of heterogeneity followed by subgroup analyses stratified by variables that significantly impact survival estimates. In total, this study …
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Histopathological Changes in Dental Pulp Associated with Periodontitis: A Systematic Review and Meta Analysis
… using random-effects models to estimate pooled prevalence and odds ratio, with heterogeneity assessed by I² and τ² statistics. Results: Teeth with periodontitis were significantly more likely to exhibit histopathological changes compared to controls. The odds ratio (OR) for calcification …
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Methods and models of screening genomic variants
… in RNA-guided endonucleases have enabled such pooled screens in human cells. I first consider a model to understand drivers of immune evasion in a pooled knockout screen conducted in an in vitro model of metastatic melanoma. Next, I discuss strategies for scaling these screens to encompass a …
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Fiber Type-specific Desmin Content in Human Single Muscle Fibers
… Following identification, muscle fibers were pooled into two groups (MHC I and MHC IIa). Desmin and actin content within the pooled samples was determined via immunoblotting. On average, muscle samples were composed of 51 ± 7 % type I, 2 ± 1% type I/IIa, 27 ± 5% type IIa, 19 ± 4% type IIa/IIx …
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An evaluation of the removal method for estimating benthic populations and diversity
… of representing rare species, and as expected, pooled removal collections accumulated species at a higher rate than the pooled collections of other methods. The dominance diversity of pooled CDS collections became stable more rapidly than those of other methods, and gave higher resolution …
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