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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Polyunsaturated fatty acids (PUFAs)"”.
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The effects of Omega-3, Omega-6 Polyunsaturated Fatty Acids (PUFAs) and Vitamin E on patients with the remitting-relapsing (RR) form of Multiple Sclerosis (MS) in Cyprus
… susceptible genetic background. Omega (ω)-3/ω-6 polyunsaturated fatty acids (PUFAs) and some vitamins have been shown to reduce the number and severity of relapses and the overall progression of disability in multiple sclerosis patients, however clinical trials remain inconclusive due to a …
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ROLE OF 12/15 LIPOXYGENASE EXPRESSION IN LIPID METABOLISM, ATHEROSCLEROSIS AND INSULIN RESISTANCE
… the stereospecific incorporation of oxygen into polyunsaturated fatty acids (PUFAs), forming a series of bioactive lipid mediators. Though lipid mediators produced by 12/15LO have the potential to affect lipid metabolism and atherosclerosis, the role of 12/15LO expression in these processes has …
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The effect of free fatty acids on endothelial cells
… lipoprotein (OxLDL) molecules e.g. oxidized polyunsaturated fatty acids (PUFAs), or saturated free fatty acids (FFA) are alone sufficient to decrease endothelial cells. This hypothesis was tested by incubating porcine aortic endothelial cells (PAECs) with various oxidized PUFAs and saturated …
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Raman spectroscopic analysis of fatty acids in tumor micro- and macroenvironments in breast cancer
Fatty acids play essential roles in the growth and metastasis of cancer cells. To facilitate their avid growth and proliferation, cancer cells not only alter the fatty acid synthesis and metabolism intracellularly and extracellularly, but also in the macroenvironment via direct and indirect …
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Functional Study of Lipoxygenase-mediated Resistance to Fungal Pathogens in Maize for Milk-chain Safety and in Grapevine for Sustainable Viticulture
… Lipid membrane modification and peroxidation of polyunsaturated fatty acids (PUFAs) into oxylipins are reported in plants as a response to fungal pathogens. In this respect, lipoxygenase genes (LOXs) play a crucial role in the peroxidation of polyunsaturated fatty acids (PUFAs) into 9(S)- and …
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Methyl esterification of fatty acids and eicosanoids with a novel reagent trimethylsilyldiazomethane for analysis by gas chromatography-mass spectrometry
<p>Fatty acids are compounds with limited water solubility that belong to the lipid class of bio-organic compounds and can be utilized as a source of energy by the body or as precursors to oxidized compounds that have roles in inflammation and in the regulation of vascular tone. The prostaglandins …
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THE ROLE OF BOTANICAL OILS ENRICHED IN FADS2-DERIVED N-3 VS. N-6 POLYUNSATURATED FATTY ACIDS IN PREVENTION OF ATHEROSCLEROSIS
Background: Dietary polyunsaturated fatty acids (PUFAs) reduce atherosclerosis in animal models and humans relative to dietary saturated and monounsaturated fatty acids. Although some of the atheroprotection of dietary PUFAs is due to plasma lipid lowering, in vivo conversion of 18 carbon PUFAs …
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FATTY ACIDS IN PHYSIOLOGY AND PATHOLOGY: FOCUS ON ALPHA-LINOLENIC ACID (ALA) AND PUFAS
… the clinical and pathophysiological roles of polyunsaturated fatty acids (PUFAs), focusing on alpha-linolenic acid (ALA), and linoleic acid (LA), within a broad range of human biological processes. PUFAs are essential nutrients involved in modulating cell membrane fluidity, intracellular …
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Evidence for the role of delta-6-desaturase in the development of cardiometabolic disease
… tested the general hypothesis that changes in fatty acid membrane composition found to be associated with cardiometabolic disease are attributed to delta-6-desaturase activity and contribute to the development of disease. The specific aims of each experimental series were to: 1) Determine …
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A multifactorial investigation of the capacities of lipid-soluble dietary antioxidants to suppress the thermally induced generation of Lipid Oxidation Products and alternative methods of detection.
… was able to determine and assess the impact of fatty acid content across nine culinary oil products, demonstrating elevated aldehyde formation in oil products rich in polyunsaturated fatty acids (PUFAs), relative to monounsaturated fatty acid (MUFA) and saturated fatty acid (SAFA) rich oils. …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… and T2DM. Palmitate, the predominant saturated fatty acid elevated in the blood plasma of obese individuals, induces ER stress and insulin resistance in skeletal muscle. However, the interaction between ER stress, lipid metabolism and T2DM remains poorly understood. This thesis uses lipidomic …
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Identification of Host Factors Required for Hepatitis C Virus Infection
… that when HCV-infected cells were exposed to polyunsaturated fatty acids (PUFAs) in the absence of lipid-soluble antioxidants, a dramatic increase in lipid peroxidation caused a reduction in HCV RNA. Because peroxidation of PUFAs only occurs in HCV-infected cells that produce ROS, PUFAs could …
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Biotransformation of blood long-chain fatty acids and oxylipins in peripheral tissue during hemodialysis
… hemodialysis (HD). The role of long-chain fatty acids (LCFAs) and their oxylipin derivatives is poorly understood in human cardiac and renal diseases. Based on previous scientific findings, there is evi-dence that many substance profiles of blood LCFAs and their oxylipin derivatives are …
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Effect of UV-A irradiance on lipid accumulation in Nannochloropsis oculata
… and structural lipids, which are composed of polyunsaturated fatty acids (PUFAs). PUFAs are essential nutrients for both aquatic animals and humans, while TGs can be transesterified to produce biodiesel. Lipid formation in microalgae depends on several environmental factors and …
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The development of new methods for the assessment of oxygen radical-mediated oxidative damage to biomolecules with special reference to lipids
… the extent of RORS-dependent peroxidation of polyunsaturated fatty acids (PUFAs) has been further developed for application to biological samples. This technique involves the conversion of conjugated hydroperoxydienes and compounds derived therefrom, i.e. oxodiene and hydroxydienes, to …
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Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease
… and specific “healthy” diet components, such as polyunsaturated fatty acids (PUFAs), have been hypothesized to reduce the risk of CVD. However, results from epidemiological studies have been conflicting. This may be due to individuals having varied genetic profiles that are differentially …
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The effects of altered membrane fatty acid composition on the toxic interactions of heavy metals with Saccharomyces Cerevisiae
The effects of altered membrane fatty acid composition on the toxic interactions of heavy metals with Saccharomyces cerevisiae were examined. Saccharomyces cerevisiae was enriched with the polyunsaturated fatty acids (PUFAs) linoleate (18:2) and linolenate (18:3) by growth in 18:2- or …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
Omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), possess anti-inflammatory properties and are a source for bioactive lipid metabolites. Dietary EPA and DHA are converted to omega-3 endocannabinoids (eCBs), eicosapentaenoicethanolamide …
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ENHANCING SUSTAINABLE FEED PRODUCTION: UTILIZING AGRICULTURAL WASTES AS SUBSTRATES FOR BLACK SOLDIER FLY LARVAE CULTIVATION
… growing substrates aimed at enhancing the fatty acid profile of BSFL. While BSFL is acknowledged as a nutritious feed option, it typically lacks essential omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) found in fish meal, a popular albeit expensive alternative. Previous research …
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Salmon In Pregnancy Study (SIPS): the effects of increased oily fish intake during pregnancy on maternal and cord blood fatty acid composition, cord blood immunity and atopy outcomes in infants at 6 months of age
… diets have become increasingly rich in n-6 polyunsaturated fatty acids (PUFAs) and relatively deficient in n-3 PUFAs. These dietary changes are believed to promote a pro-sensitisation, pro-allergic and pro-inflammatory environment. Exposure to such an environment during pregnancy and in the …
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