Global ETD Search
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Showing 1 to 5 of 5 for “"Polytopic membrane protein"”.
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Purification of Native and Recombinant NPC1
The Niemann-Pick, Type C1 protein (NPC1) is required for the transport of lipoproteinderived cholesterol from lysosomes to endoplasmic reticulum. The 1278-amino acid, polytopic membrane protein has not been purified, and its mechanism of action is unknown. We encountered NPC1 in a search for a …
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Ceramide-Induced Alternative Translocation of TM4SF20
The polytopic membrane protein TM4SF20 (transmembrane 4 L6 family 20) is a protein containing four transmembrane helices that inhibits the Regulated Intramembrane Proteolysis (RIP) of the transcriptional factor CREB3L1 (cAMP response element binding protein 3-like 1), a transcription factor …
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Biogenesis and Traffic of the Potassium Channel
… types of ion channels expressed at the plasma membrane. This work examines aspects of biogenesis and traffic of the Shaker voltage-gated potassium channel. Shaker is an oligomeric, polytopic membrane protein and, as such, its biogenesis begins at the endoplasmic reticulum (ER). I have studied …
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SCAP, Insig, and Cholesterol Interactions in Mammalian Cells
… controlled by sterol regulatory element binding proteins (SREBPs). The critical regulatory step is the proteolytic release of SREBPs from their inactive membrane bound form. Soon after translation, SREBPs bind SREBP cleavage activating protein (SCAP), a polytopic membrane protein of the …
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Mechanisms of multipass membrane protein biogenesis
… reagents to improve efficiency. Semi-permeable membranes facilitate autonomy via an outer barrier (plasma membrane) and enclose functional hubs (organelles) to efficiently carry out biological processes. However, cells do not live in isolation and must communicate with neighboring cells, uptake …