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Showing 1 to 6 of 6 for “"Polyrotaxane"”.
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SYNTHESIS, CHARACTERIZATION, IN VITRO EVALUTION, AND PRECLINICAL PROFILING OF β-CYCLODEXTRIN POLYROTAXANE FAMILIES FOR USE AS POTENTIAL NIEMANN-PICK TYPE C THERAPEUTICS
Niemann-Pick Disease Type C (NPC) is a rare, autosomal recessive genetic disorder featuring a loss of proteins responsible for unesterified cholesterol (UC) trafficking through the late endosomes/lysosomes (LE/LY) of every cell of the body. Disruption of this pathway leads to abnormal accumulation …
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Novel polymer architectures: polyrotaxanes
… threaded by linear macromolecules and are called polyrotaxanes. Polyrotaxanes are considered to be physical analogs of block or graft copolymers or molecular interpenetrating systems. The design and synthesis of the macrocyclic component, "blocking groups" to constrain the macrocycles and the …
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New polymer architectures: synthesis and characterization of polyurethane-crown ether based polyrotaxanes
… architectures. Unlike conventional polymers, polyrotaxanes are molecular composites comprised of macrocycles threaded by linear polymer backbones with no covalent bonds between the two components. This novel class of materials displays unusual chemical and physical properties due to their …
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Synthesis and performance of novel supramolecular tools for single-particle cryogenic electron microscopy and drug and gene delivery
… gold standard resolution of 8.1 Å. A library of polyrotaxanes based on PEG, ?-CD and various endcaps and rotaxanation methods was synthesized. Several of these compounds were further modified with NTA moieties to impart affinity interactions on the tubular polyrotaxane templates which might be …
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Linear, Branched and Crosslinked Polymers, Polyesters, Polyurethanes and Polymethacrylates Derived From Rotaxane Formation: Syntheses and Properties
As new family of composite materials, polyrotaxanes, polymers containing rotaxane units, have interested scientists world wide in last few decades because of their new properties. Crown ethers have been widely used as the cyclic component in various polyrotaxanes. However, due to significant loss …
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Supramolecular architectures: macrocycles, catenanes and polyrotaxanes
Polyrotaxanes are molecular composites consisting of three components: linear polymers, bulky stoppers at the ends of polymer chains and macrocycles threaded by the polymers. A series of tetraarylmethyl derivatives as blocking groups were synthesized. Using tris(p-ten-butylphenyl)( …