Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Polypyrimidine tract binding protein"”.
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Investigation of the Polyprimidine Tract-Binding Protein-Associated Splicing Factor (PSF) Domains Required for the Hepatitis Delta Virus (HDV) Replication
… of HDV implies on investigating the host proteins that bind to its genome. The polypyrimidine tract-binding protein-associated splicing factor (PSF), an HDV interacting protein, was found to interact with the carboxy terminal domain (CTD) of RNA polymerase II (RNAPII), and to facilitate …
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Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
… homeostasis, and PACS-1 regulation of membrane protein trafficking within the regulated secretory pathway. First, our results establish PACS-1 motifs that regulate nuclear localization through the classical nuclear trafficking pathway. Moreover, we have identified a novel interaction between …
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Glycine receptors in the developing rat spinal cord
… antigen-1 (Nova-1) and the brain isoform of the polypyrimidine tract binding protein (brPTB). Treatment of neurons in culture with antisense oligonucleotides to "knock down" one of the Nova-1 variants altered the expression of GlyR α2N. These results suggest that the relative levels of the …
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Interactions between Nova and brPTB Proteins in Alternative Splicing and Nuclear Localization
… paraneoplastic antigens are neuron-specific RNA-binding proteins that are essential for neuronal viability and participate in the control of alternative splicing. In this study, the yeast two-hybrid system is used to isolate Nova-1nteracting proteins. A novel RNA-binding protein named brPTB is …
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Mechanisms of Regulation of Tau Ires Mediated Translation
… in order to regulate the expression of the tau protein.</p> <p>Tau protein is ubiquitously expressed but is concentrated in the brain. In this study, I utilized neural and non-neural cell lines to show that tau IRES is utilized differently (in some cases, up to 50% of total tau translation) …
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Unique Features of PTB RRMs: Insight into Protein Motions and RNA Binding
Polypyrimidine tract binding protein: PTB) is a highly conserved RNA binding protein comprised of four RRMs: RNA recognition motifs). RRMs are extremely prevalent in all kingdoms of life, and have been very well characterized in terms of structure and RNA binding properties. However, all four RRMs …