Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"Polyposis"”.
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Antigenexpression von Entzündungszellen bei Polyposis-nasi-Patienten
Die Ätiologie und Pathogenese der Polyposis nasi ist trotz intensiver Forschung bis heute in vielen Zügen ungeklärt. Deshalb wurde eine histologische und immunhistochemische Arbeit bezüglich Pathomorphologie sowie Vorkommen, Häufigkeit und Verteilung von immunkompetenten Zellen bei Nasenpolypen mit …
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Familial adenomatous polyposis: a genotype - phenotype correlation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Novel interactions and functions of the Adenomatous polyposis coli protein
Mutations of the Adenomatous polyposis coli (APC) gene are a frequent and early event in the development of sporadic colorectal cancer and also form the genetic basis of familial adenomatous polyposis. APC is an established regulator of the cytoskeleton, however, the tumour suppressive function of …
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Hereditary non-polyposis colorectal carcinoma (HNPCC) : morphological and immunohistochemical studies
Families with hereditary non-polyposis colorectal carcinoma (HNPCC) are not uncommon along the West-Coast of South Africa. These patients present with early onset carcinomas mostly colorectal, predominantly in the right colon. They may develop tumours of other organs, including uterus, breast, …
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Availability of Dental Anomaly Phenotype In Individuals With Familial Adenomatous Polyposis
… the <em>APC</em> gene cause familial adenomatous polyposis (FAP), an autosomal dominant colorectal cancer predisposition associated with the development of hundreds to thousands of adenomatous colorectal polyps beginning in childhood or adolescence. Both malignant and non-malignant extracolonic …
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Genomic Characterization of Polyps In Familial Adenomatous Polyposis Patients and Identification of Candidate Chemopreventive Drugs
<p><em>Familial adenomatous polyposis</em> (FAP) is an autosomal dominant disease characterized by <em>APC</em> germline mutations and the development of hundreds to thousands of premalignant adenomas in the gastrointestinal tract at a young age. If left untreated, these patients inevitably develop …
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Identifying and characterizing hereditary polyposis and colorectal cancer: Mutational signatures of defective base excision repair
Contains fulltext : 239215.pdf (Publisher’s version ) (Open Access)
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EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
… and eosinophils in the pathogenesis of nasal polyposis, is by antagonizing IL-5 in an interventional study in NP patients. However, eosinophils show varying IL-5 sensitivity due to a different expression of the IL-5R isoforms according to activation state, maturation and localization in the …
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Vergleichende Untersuchung zu Lebensgewohnheiten und Lebensumfeld von Patienten mit selbstberichteter Multipler Chemikaliensensitivität, Duftstoffallergien oder Polyposis nasi
… sensitivity (MCS), fragrance allergies (FA) and polyposis nasi (PN). Besides other organ systems, a joint effect organ of MCS, FA and PN is the respiratory tract. Therefore, aim of the present study was to characterize and compare living conditions and living factors of persons with self-reported …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
Adenomatous polyposis coli (APC) is a tumor suppressor gene that is mutated in the vast majority of colorectal tumors. Inactivation of this gene is a key and early event in colorectal tumorigenesis. APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… these receptors in the pathophysiology of nasal polyposis. Finally, based on our previous findings and parallel work of our group, we studied the influence of S. aureus enterotoxins in the regulation of both eosinophilic inflammatory and eicosanoid pathways. We first show that nasal …
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Communication In Family Members With A Rare APC Mutation
<p>OBJECTIVES: APC-associated polyposis is caused by mutations in the APC gene and includes familial adenomatous polyposis (FAP), an autosomal dominant cancer predisposition syndrome which has a lifetime risk of colon cancer of almost 100%. Identifying a genetic mutation can provide important …
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In vitro chemically-induced DNA damage in cancer patients and healthy individuals. The effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals.
… measured in peripheral blood lymphocytes from polyposis coli and colorectal cancer patients, treated with different dietary and environmental compounds and compared with lymphocytes from healthy individuals. In addition, confounding factors such as age, gender, alcohol intake and smoking habits …
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The molecular genetic and epidemiological investigation of colorectal cancer in South Africa
… are a dominant feature (e.g. familal adenomatous polyposis-FAP) and the non-polypotic forms (e.g. hereditary nonpolyposis colorectal cancers-HNPCC).
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