Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Polyomavirus"”.
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An investigation into BK Polyomavirus and host-virus interactions
The potentially oncogenic human pathogen BK Polyomavirus (BKPyV) was first identified in 1971 and has since been associated with a number of diseases primarily in immunosuppressed patients. Infection is established in early life and by adulthood up to 90% of populations show seroconversion for the …
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Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA
… cancer with rising global incidence. Merkel cell polyomavirus (MCV) was discovered in 2008 in 80% of MCC samples and since then a causal link between MCV and the majority of MCC cases has been established. microRNAs (miRNA, miR) are a family of small non-coding RNAs which play a key role in …
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Investigating the mechanisms of BK Polyomavirus egress and virus-host interactions.
BK polyomavirus (BKPyV) is a small, non-enveloped dsDNA virus that infects 70 – 90% of the world’s population and causes a lifelong, silently persistent infection. In immunocompromised individuals, BKPyV replication can result in serious pathology. Bone marrow transplant patients can develop …
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REGULATION OF THE HUMAN NEUROTROPIC POLYOMAVIRUS, JCV, IN THE CENTRAL NERVOUS SYSTEM
The human neurotropic virus, JC virus (JCV), is the etiologic agent of the fatal demyelinating disease of the central nervous system, progressive multifocal leukoencephalopathy (PML) that is seen primarily in immunodeficient individuals. Productive infection of JCV occurs only in glial cells and …
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Functional characterisation of the N-terminal domain of polyomavirus large T antigen
… and brain tumours.However, the murine polyomavirus encodes for 154 additional amino acids that are rich in glycine and proline residues and could potentially play an important role towards cell transformation. Moreover, the polyoma virus protein has not been studied to this extent …
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The Art of Viral Oncogenesis: Lessons from Human Papillomavirus and Polyomavirus Transformed Cancers
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Genotypisierung des humanen Polyomavirus JC in Korea und Australien sowie erste Hinweise auf eine Infektion des Auges
Die vorgelegte Arbeit hat zwei Schwerpunkte, deren Gemeinsamkeit die Genotypisierung des JCV darstellt. Zum einen die Ergänzung der JCV-Epidemiologie in Korea und Australien. Zum anderen der Nachweis von JCV-, CMV- und HIV-DNA in Paraffinschnitten von Augen an HIV verstorbener Patienten, dessen …
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Interactions Between Host Cells And Merkel Cell Polyomavirus In The Context Of Infection And In Merkel Cell Carcinoma
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC). Epidemiological evidence suggests that poorly controlled MCPyV infection may be a precursor to …
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Cloning of a putative human oncogenic virus, BK
… leukoencephalopathy (PML) and was thus the first polyomavirus infection of humans to be discovered. (ZuRhein and Chou, 1965). In 1971, an immunologically distinct polyomavirus, BK, was isolated from the urine of an immunocompromised recipient of a renal allograft (Gardner et al., 1971). Interest …
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Polyomavirus Enhancer Activator 3 (PEA3), a Member of the Ets Family of Transcription Factors, Is a Transcriptional Activator of Notch-1 and Notch-4 in Breast Cancer: An Opportunity for Novel Combinational Therapy
… with the poorest overall survival. PEA3 (polyomavirus enhancer activator 3), a member of the Ets family of transcription factors, is overexpressed in triple-negative breast cancer and also correlates with aggressive behavior and poor overall survival. Here, we provide new evidence for …
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Role BK polyomaviru v lidských nádorech
BK polyomavirus (BKV) je malý neobalený ubikvitně rozšířený DNA virus, který u imunosuprimovaných jedinců může způsobovat závažná onemocnění, konkrétně BK polyomavirovou nefropatii (BKVaN) a hemoragickou cystitidu. Mimo toho se o BKV uvažuje jako o možném původci některých nádorových onemocnění u …
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The role of the large T antigen in the in vitro replication of BPyV
Bovine Polyomavirus (BPyV) is a member of Polyomaviridae, a family of double stranded DNA viruses. When the virus was initially discovered it was thought to be of simian origin (Wognum et al., 1984), but further research indicated that the virus was of bovine origin and that primate cultures had …
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Biochemical characterization of the nucleic acids of some human and animal viruses
… isolation and partial characterization of human polyomaviruses from a number of renal transplant patients is described. These isolates proved refractory to cell culture propagation by the methods used, and were thus extracted directly from large volumes of patient's urine. This approach has the …
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Pseudovirions in the Study of Papilloma- and Polyomaviruses
The papilloma- and polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. Detection of specific antibodies to these viruses allows tracking past and present …
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Modellverbindungen zum Studium Sialinsäure-vermittelter Erkennungsprozesse : Synthese neuer Saccharide auf Basis von Carotinoiden und Furanen
… zuckerbindender Oberflächenproteine des Polyomavirus synthetisiert. Anhand der Kristallstruktur des Kapsidproteins pv1 und der darauf lokalisierten Lektindomänen konnten optimierte multivalente Inhibitoren modelliert werden. Durch Verwendung langer, rigider Ketten (ca. 30Å) auf Basis von …
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Understanding the Role of Delta-catenin in Virus-Positive Merkel Cell Carcinoma
… often driven by the integration of Merkel cell polyomavirus (MCPyV) into the host genome and the persistent expression of its viral oncoproteins, small tumor (ST) antigen and truncated large tumor (t-LT) antigen. However, the MCC cell of origin remains unknown. Identifying the cell of origin …
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Mechanism of Human Papillomavirus E6-Mediated Repression of P53-Target Gene *Transcription
… based on the finding that SV40 large T-antigen, polyomavirus large T-antigen, adenovirus E1B 19K, and human papillomavirus E6 encoded-oncoproteins inhibited p53-dependent chromatin transcription at a step prior to the entry of p300, indicating that oncoprotein incorporation into p53-p300 complex …
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A possible mechanistic role for microorganisms in the genesis of colorectal cancer.
… compared to normal colon tissue. JCV is a polyomavirus that infects approximately 75% of the population. Polyomaviruses are DNA viruses and one of the proteins encoded in the genome is the T Antigen. The T Antigen protein is oncogenic and is capable of inactivating p53 and the pRb/p107/p130 …
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Matriptase Mediated C-Met Signaling In Breast Cancer
… When crossed into the mammary tumor virus (MMTV) Polyomavirus middle T (PymT) mouse genetic mammary tumor model, matriptase hypomorphic mice displayed a significant decrease in tumor burden. </p> <p>The hepatocyte growth factor (HGF)/c-Met signaling pathway is dysregulated in breast cancer and has …
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