Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Polynucleotide phosphorylase"”.
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Analyzing the functions of human polynucleotide phosphorylase (hPNPaseold-35)
… and one such evolutionarily conserved enzyme is polynucleotide phosphorylase (PNPase). The human homologue of this fascinating enzymatic protein (hPNPaseold-35) was cloned a decade ago in the context of terminal differentiation and senescence through a novel ‘overlapping pathway screening’ …
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Degradation of 23S rRNA in Azithromycin-Treated Ribonuclease Mutants of <em>Escherichia coli</em>.
… with a 23S specific probe. Ribonuclease II and polynucleotide phosphorylase mutants demonstrated hypersensitivity to the antibiotic and showed a greater extent of 23S rRNA accumulation, suggesting that these two ribonucleases are important for 23S rRNA turnover in azithromycin-treated …
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Environmental sensing and response of conserved RNA-processing machines to specific external chemical cues
… and/or interactions with regulatory molecules: polynucleotide phosphorylase and the ribosome. Both of these machines are multi-subunit and homologs retain similar functions in all three domains of life. The ribosome is the translational machinery of the cell, whose primary function is to …
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Fantastic ribonucleoprotein complexes and how to study them. Architectural principles of regulatory assemblies in bacteria.
… repurposing the conserved ribonuclease PNPase (polynucleotide phosphorylase) into an RNA chaperone. Cryo-EM structures presented here show how the flexible KH-S1 portal of PNPase generally guides the 3ʹ-end of the sRNA sponge 3ʹETSleuZ to the catalytic core for digestion but reroutes the sRNA …