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Showing 1 to 20 of 51 for “"Polymyxin"”.
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Studies on the stability and activity of polymyxin B solutions.
… stability and the microbiological activity of polymyxin B in phosphate buffer pH 6.0 and in proprietary eye drops was evaluated. High Performance Liquid Chromatography (HPLC) was used to quantify the amount of the main components in samples stored at 43,50,55 and 60°C for a period of 500 h. …
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Stress And Survival Of Enterobacteriaceae: Studies Of Dehydration Tolerance And Polymyxin Resistance
… how Enterobacteriaceae adapt to dehydration and polymyxins. Dehydration is an environmental stress that many bacteria encounter in their ecological niches. However, the mechanisms involved in surviving dehydration are not well understood, particularly in Gram-negative bacteria. In Chapter 2 we …
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Studies on the Mechanism of Action of the Peptide Antibiotics, Polymyxin B and Em 49. (Octapeptin)
Made available in DSpace on 2014-12-14T04:27:39Z (GMT). No. of bitstreams: 1 7726742.pdf: 7374914 bytes, checksum: 5b402efe22870e63b3b6a41d816838af (MD5) Previous issue date: 1977
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Examination of the antibacterial activities of some semi-synthetic chalcone-derivatives alone and in combination with polymyxin B.
… synergistic action when used in conjunction with polymyxin B against S. aureus, C. violaceum, E. coli and PS. aeruginosa. In these cases, they demonstrated FICs from less than 0.093 to 2. The compounds also demonstrated a FIC index of less than 0.093 when applied with polymyxin B against …
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Evaluation of the immunomodulatory activity of Plasmodium falciparum hsp70-1
… explain its apparent immune modulatory function. Polymyxin-B has routinely been used to neutralise the adverse effects of LPS from recombinant Hsps produced using traditional E. coli. Polymyxin-B is a cationic cyclic antibiotic that binds and aggregates LPS. However, the effects of polymyxin-B …
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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity
… experiments, dams were fed vancomycin, polymyxin B, or both, in drinking water during gestation, nursing or gestation plus nursing, and their offspring microbiota analysed at 14 days of life, alongside immunity in the spleens. Offspring born to vancomycin treated mothers had …
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Oxidative stress and nitrosative stress, their interaction and implications for bioprocessing
… here show that increasing concentrations of polymyxin B, added to a bioreactor, increase oxidative stress during cultivation of Aspergillus niger B1-D in a bioreactor. This was shown by the increased superoxide dismutase (SOD) and catalase (CAT) activities after addition of polymyxin B. This …
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Development of techniques for the recovery and enumeration of two mosquito pathogens
… NY medium. One medium contained 100 µg/ml of polymyxin with 1.0 µg/ml chloramphenicol (NYPC), and the other contained 500 µg/ml of polymyxin alone. The use of the higher level of polymyxin with chloramphenicol reduced the number of viable B. thuringiensis serovar. israelensis. NYPC was used to …
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Intracellular growth of Brucella abortus and B. melitensis in murine macrophage-like cell lines and partial characterization of a biologically active extract from B. abortus strain RB51
… the S2 extract is the lipopolysaccharide (LPS). Polymyxin B is thought not to bind B. abortus LPS as it does not contain 3-myristic acid. However, it was important to evaluate the role, if any, of LPS contamination of the S2 extract in the in vitro responses observed with splenocytes from mice …
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Novel antimicrobial combinations for treatment against pathogens associated with infected diabetic foot ulcers
… formulations (chlorhexidine-LQ (CHLX-LQ), polymyxin B-LQ, polymyxin E-LQ, linezolid-LQ and poly-ε-lysine-LQ) showed improved antimicrobial activity against test organisms. On the other hand, the free LQ nanoparticle without antimicrobial had no effect on viable cells. Novel polymyxin B and …
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Identification of new therapeutic compounds against carbapenemase-producing Klebsiella pneumoniae using a novel agar-based high-throughput microarray compound screening approach
… were observed on the platform, with three (polymyxin B sulfate, colistin sulfate, and gentamicin sulfate) and two (polymyxin B sulfate and colistin sulfate) test drugs showing antibacterial activity against K. pneumoniae 1705 and 700603, respectively. Drugsusceptible K. pneumoniae 33495, E. …
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ΕΠΙΔΡΑΣΗ ΤΩΝ ΑΜΙΝΩΝ ΣΤΙΣ ΔΟΜΙΚΕΣ ΚΑΙ ΚΑΤΑΛΥΤΙΚΕΣ ΙΔΙΟΤΗΤΕΣ ΤΗΣ ΓΛΥΚΟΓΟΝΙΚΗΣ ΦΩΣΦΟΡΥΛΑΣΗΣ Β
… THE ALIPHATIC AMINES, THE PHENOTHIAZINES AND THE POLYMYXINS. THESE AMINES IN THE PRESENCE OF AMP INDUCE A SIGNIFICANT ENHANCEMENT OF ENZYME ACTIVITY. THE BINDING CENTER OF PHOSPHORYLASE B FOR AMINES IS POSSIBLY LOCATED ON THE N-TERMINAL CHAIN OF PHOSPHORYLASE B. FROM ALL AMINES, POLYMYXIN B IS THE …
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Liposomes as carriers for polymyxins in the treatment of cystic fibrosis lung infections
… Recently, attention has focused on aerosolised polymyxins, which are given prophylactically in an effort to limit infection and subsequent lung damage. This class of antimicrobial compounds is highly active against P. aeruginosa and possess the advantage that resistance rarely develops. However, …
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The microbiology of diabetic foot infections: a Ghanaian perspective
… and QS inhibitors/antimicrobial peptides such as polymyxin B and polymyxin B nonapeptide determined as fractional inhibitory concentration (FIC) index suggests that, additive and synergistic effects produced by the combination of two antimicrobial agents have the potential to eradicate biofilms. …
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The Effect of Environment on Virulence Factors and Resistance of Mucoid Strains of Pseudomonas Aeruginosa
… in their susceptibility to carbenicillin, polymyxin and deoxycholate with and without added magnesium. WT produced two major phenotypes which differed in colony size and appearance on nutrient agar. Both showed differences in the production of the virulence factors, protease, elastase, …
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Antimicrobial Effectors Act Cooperatively to Stress Salmonella in the Macrophage Phagosome
… virulence. We have found that osmotic shock and polymyxin B treatment are analogous. SodCII is preferentially released by polymyxin B, while SodCI is retained. Likewise, mouse macrophage Cathelicidin-related antimicrobial peptide (CRAMP) treatment leads to SodCII release, while SodCI is tethered …
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Campylobacter fetus subspecies jejuni from some commercially processed poultry products
… and antibiotic (bacitracin, novobiocin and polymyxin) medium was described and utilized to isolate the organism from the surface of chicken necks contaminated in vitro and from retailed commercially processed poultry products. In a survival study one C. fetus strain remained viable for 5 …
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Optimization of Cryopreservation Protocols for Cardiovascular Tissue
… were toxic to the cells. Cefoxitin, lincomycin, polymyxin B, vancomycin and penicillin had no apparent effect on viability of cells in heart valve tissue. The study also revealed that antibiotic solution (amphotericin B, cefoxitin, polymyxin B, lincomycin, vancomycin) utilized to disinfect tissue …
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The effect of antibiotics on Pseudomonas aeruginosa biofilm production
… of 0.07mg/mL for gentamicin, rifampicin, and polymyxin B. These antibiotics were used to test 48 clinical samples obtained in 2006. Out of the 48 isolates, a Pseudomonas strain of unknown origin was resistant to both gentamicin and rifampicin (p<0.001). Extraction of Colicin V from E. coli and …
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Investigating Hfq-dependent Small Regulatory RNA, Bsr34, and Its Roles in Brucella abortus Physiology and Pathogenicity
… downregulated under envelope stress (polymyxin B) and acidic pH, but not under oxidative or nutrient stress. Collectively, these findings establish Bsr34 as a bona fide Hfq dependent sRNA involved in host-specific adaptation and stress response, laying the groundwork for future studies …
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