Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 840 for “"Polymorphisms"”.
-
Gene polymorphisms in SLE
Systemic lupus erythematosus (SLE) is an autoimmune disease, with a strong genetic component. It is characterised by hyperactive T and B cells, chronic inflammation and the production of antinuclear autoantibodies. SLE affects mostly women of child baring age, with a 9:1 ratio, women to men and has …
-
Identification of DNA polymorphisms
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Interdisciplinary Science, 1982.
-
Polymorphisms in heat shock protein receptors
Das extrazelluläre Hitzeschockprotein 70 (Heat Shock Protein 70, HSP70) kann als immunologisches Gefahrensignal fungieren und stimuliert die Aktivität zytotoxischer T-Lymphozyten und natürlicher Killerzellen. In diesem Kontext stellt HSP70 ein vielversprechendes Werkzeug im Rahmen immunologischer …
-
The Use of Genetic Polymorphisms and Discriminant Analysis in Evaluating Genetic Polymorphisms as a Predictor of Population
… predictor variables. Data bases of genetic polymorphisms are currently available that group such polymorphisms by ethnic origin or nationality. Such information could be useful to entities that base financial determinations upon predictions of disease or to medical researchers who wish to …
-
Analyse von Single Nucleotide Polymorphisms an Glas-Oberflächen
Ziel der vorliegenden Arbeit war die Entwicklung einer SNP-Genotypisierungsmethode mit auf Mikroarrays immobilisierten PCR-Produkten. Für die Analyse wurde ein faseroptischer Affinitätssensor bzw. ein Durchfluss-Biochip-Scanner mit integrierter Fluoreszenzdetektion verwendet. An den immobilisierten …
-
Sleepers and Creepers, Colony Polymorphisms in Metarhizium robertsii
… provide a framework to explain the colony polymorphisms seen in M. robertsii. This work is based on the observation of three distinct phenotypes: a highly conidiating phenotype (Sleeper), a primarily hyphal phenotype (Creeper) and an intermediary (Mixed) phenotype that represents the middle …
-
Multiplexed genotyping of single nucleotide polymorphisms using microarray technology
This thesis was composed of four separate studies. The first study was initiated to adapt minisequencing to solid support to interrogate multiple SNPs which had been reported to be associated with coronary artery disease. This microarray-based platform has demonstrated a great potential for highly …
-
Genetic Polymorphisms of Interleukin-6 in Systemic Lupus Erythematosus
… inflammatory and immune responses, and IL-6 gene polymorphisms are known to play a part in chronic inflammatory and autoimmune disorders. We have identified single nucleotide polymorphisms (SNPs) in the IL-6 gene, determined their frequency in Korean populations, and elucidated their difference …
-
Single Nucleotide Polymorphisms Linked to Essential Hypertension in Kasigau, Kenya
… In this study, three single nucleotide polymorphisms (SNPs) known to be linked to an increase in susceptibility to EH were quantified from a cohort of Kenyans living in the Kasigau region. The SNPs are located in three genes that are part of the renin angiotensin system, the primary …
-
Single Nucleotide Polymorphisms in the Folypoly-gamma-glutamate synthetase Gene
… of FPGS. Consequently, any single nucleotide polymorphisms (SNPs) that exist in the fpgs gene may decrease or increase the cytotoxicity of antifolates and, ultimately, the clinical response rate to antifolate therapy. The goal of this project is to define the position and frequency of single …
-
Biological and functional consequences of polymorphisms in the XPD gene
… many associations between single nucleotide polymorphisms (SNPs) in the nucleotide excision repair gene XPD (ERCC2) and cancer risk. Little is known, however, about the underlying mechanisms for these associations. I used lymphocytes from healthy subjects to explore novel mechanisms which …
-
Characterisation Of Cytokine Gene Polymorphisms In Patients With Acute Pancreatitis
… IL-10.G microsatellite locus, and 3 hi-allelic polymorphisms in the 5' flanking region of the IL-l 0 gene were typed using the polymerase chain reaction. Results There was no difference in allelic frequency of any of the cytokine gene loci between groups stratified according to disease severity. …
-
Human C-band chromosomal polymorphisms: frequency and distribution in Orientals
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Genetic Effect of ALOX15 Polymorphisms on Aspirin-Exacerbated Respiratory Disease
… healthy controls (NC) were enrolled. Three polymorphisms (-427G/A, -272C/A, -217G/C) in the promoter were genotyped by a primer extension method. The functional variabilities of the promoter polymorphisms were analyzed by luciferase reporter activity assay, electrophoretic mobility shift …
-
JAMALAH--a system for the detection of single nucleotide polymorphisms
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
-
Ranking single nucleotide polymorphisms with support vector regression in continuous phenotypes
… used to improve the ranking of single nucleotide polymorphisms (SNPs) over traditional chi-square tests in disease case studies [2]. In this investigation, ranking SNPs with support vector regression (SVR) was compared to the Wald test in predicting continuous phenotypes. SVR-ranked SNPs …
-
Genetic polymorphisms in breast cancer in relation to risk and prognosis
… work the combination of lifestyle and genetic polymorphisms on tumor characteristics and early recurrence have been studied. Absence of the common 19 CA repeat allele in the insulin-like growth factor 1 gene (IGF1-19/-19) has been shown to modify the effect of several breast cancer risk …
-
Application of single nucleotide polymorphisms (SNPs) to forensic casework in Malaysia
… identification and analysis of single nucleotide polymorphisms (SNPs) have demonstrated the advantage of these markers over short tandem repeats (STRs) in that they only require small amplicons. However, before applying to casework, it is important to develop allele frequency databases from …
-
Association Study of CHRM2 Polymorphisms with Substance-Use Pathology and Personality Traits
… no clear evidence of association of CHRM2 polymorphisms with broad personality traits or substance-abuse pathology. However, the validity of our results is considerably limited by the non-multivariate-normal distribution of the substance-use pathology variable, incompleteness of the …
Page 1 of 42