Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Polymersomes"”.
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Nanoemulsion-like Polymersomes for Nanoreactors
… Phase transfer of IL-filled polymer vesicles (polymersomes) from the IL phase to water produces a very stable kind of "nanoemulsion"�. Nanoemulsion-like polymersomes have great potential as they confine a catalyst within the interiors, thus mitigating the mass transfer limitations of ILs while …
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Fabrication of Polymersomes using Microfluidic Devices
… of diblock copolymer vesicles, so-called polymersomes, from poly(2-vinylpyridine)-block-poly(ethylene glycol) (P2VP-b-PEG) and poly(ethylene glycol)-block-poly(lactid acid) (PEG-b-PLA) by means of microfluidics is described. The experiments were performed in microfluidic devices made by …
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Ellipsoidal polyaspartamide polymersomes with enhanced cell-targeting ability
Nano-sized polymersomes functionalized with peptides are being increasingly studied for targeted delivery of diagnostic and therapeutic molecules. Earlier computational studies have suggested that ellipsoidal nanoparticles, compared to spherical ones, display enhanced binding efficiency with target …
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Worm-shaped polymersomes and their effects on targeting efficiency
In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability …
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Reversibly Photo-Crosslinkable Polycarbonate-Based Polymersomes for Drug Encapsulation and Delivery
This thesis describes the preparation of polymersomes from poly(ethylene glycol)-block-polycarbonate (PEG-PC) copolymers functionalized with pendant coumarin groups. Coumarin groups undergo photo-reversible dimerization when irradiated with specific ultraviolet wavelengths, so they can be used to …
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ABC terpolymers : micelles, polymersomes and stabilisation of water in water emulsions
Polymersomes are vesicles formed from block copolymers. Their large internal volumes and thick walls make them very attractive for the encapsulation of different species. However, a major issue which prevents the use of polymersomes in most of the applications is that the encapsulation efficiency …
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Delivery of Myoglobin Polymersomes Results in Tumor Hemorrhagic Necrosis and Enhanced Radiation Response
… the biodistribution and pharmacokinetics of polymersomes</p><p>2. Establish the effects of Mb-containing polymersomes on tumor physiology</p><p>3. Modify tumor growth through delivery of Mb polymersomes in combination with a cytotoxic therapy specific to aerobic tumors</p><p>These aims have …
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Design and development of stimuli-responsive materials: pH sensitive polymersomes and poly(olefin sulfone)s
… of acid-triggerable covalently-crosslinked polymersomes and 2) the design and synthesis of base-, heat-, and fluoride-sensitive poly(olefin sulfone)s. Polymersomes are a useful approach for encapsulation but are susceptible to environmental stressors and leakage. By tuning the nanoscale …
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Large Two-photon Absorption of Highly Conjugated Porphyrin Arrays and Their in vivo Applications
… window and the utilization of nanoscale polymersomes that disperse these highly conjugated porphyrin arrays in their hydrophobic layer in aqueous environment. The NIR-emissive polymersomes, highly conjugated porphyrins-dispersed polymersomes, possess superb two-photon excited brightness. …
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Developing tissue engineered models of oral mucosa and oral cancer to study novel therapeutic and diagnostic techniques.
… spheroids were used to test the behaviour of polymersomes, a novel drug delivery system, in three dimensional tissues. Polymersome distribution and penetration in the tissue engineered models was examined over time, to investigate the potential of polymersomes to deliver therapeutic agents …
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Photoresponsive nanosystems for therapeutic applications
… antitumoral and antibacterial activity of polymersomes containing a nitric oxide photoprecursor by covalent and non-covalent approach.
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BIOMOLECULAR PRINTING FOR ARTIFICIAL LIFE-INSPIRED COMPARTMENTS AND SINGLE-CELL ARRAYS
… new method for the preparation of pH-responsive polymersomes, artificial polymeric vesicles usable as stimuli-responsive nanocarriers for fluorescent anticancer drugs, such as doxorubicin. The polymersomes dispersions were obtained from the synthesis of the polymer components. Initially, a new …
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The α-helical conformation of polypeptides: design, regulation, and applications
… as building blocks for vesicular self-assembly. Polymersomes with densely packed multilayer membrane structures were observed when PEG was used as the randomly coiled hydrophilic block.
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Amphiphilic Diblock Copolymers: Study of Interpolyelectrolyte Complexation in Organic Media and Nanoencapsulation of Melatonin
… the excess polymeric component or of vesicles (polymersomes). In system (ii), particles of micellar type with a core assembled from electrostatically coupled segments of the polymeric components can be found, surrounded by a corona built up either from a mixture of polystyrene blocks and excess …
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Development of drug delivery composite systems based on stimuli responsive segmented polymers
… για τον σχηματισμο των πολυμεροσωματων (polymersomes). Το πολυμερες αποτελειτο απο ενα pH-ευαισθητο poly(2-vinylpyridine) (P2VP) κεντρικο μπλοκ, φεροντας και στις δυο ακρες υδροφιλικο poly(ethyleneoxide) (PEO) (PEO-P2VP-PEO τριμπλοκ συμπολυμερες) και προστατευομενο στο ακρο με υδροφοβικη …
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Self-assembly of bioactive or electrocatalytic polyaspartamide nanoparticles
Submicrometer sized particles are being extensively studied because of their potentials to deliver various molecular drugs and imaging contrast agents to target diseased tissue and also support electrocatalytic activities of metallic particles. Successful use of nanoparticles in these biological …