Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"Polymeric Nanoparticles"”.
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Enhanced polymeric nanoparticles for gene delivery
… is currently ineffective. Here, we show that polymeric nanoparticles composed of poly([beta]-amino esters) (PBAEs) and DNA can be formulated to be stable in the presence of serum proteins and have high gene delivery without toxicity to human primary cells. The biophysical properties of …
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Polymeric Nanoparticles for the Modification of Polyurethane Coatings
… non fusible nanospheres. In the case of B-M nanoparticles, the degree of cross-linking seemed independent of the amount of cross-linker used. Unlikely, B-nBMA and B-nBA nanoparticles exhibited increasing degrees of cross-linking with the amount of photo-initiator introduced. Their degrees of …
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Drug Delivery to Solid Tumors via Polymeric Nanoparticles
… exposure to other body tissues and organs. Nanoparticles (NPs) have been considered a promising approach for tumor drug delivery, with popularity attributable to the famous “Enhanced Permeability and Retention effect”, where small particles enter tumor tissues through leaky vasculature and …
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Development of novel polymeric nanoparticles for pancreatic cancer therapy
… by encapsulation of chemotherapies inside nanoparticles (NPs) which have distinct physicochemical characteristics in comparison to free drugs. This enables a host of therapeutically relevant benefits such as avoidance of poorly tolerated solvents (e.g. Cremophor-EL in the case of …
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Self-assembled Polymeric Nanoparticles for Targeted Delivery of Anticancer Drugs
… The main goal of the project is to create a polymeric nanoparticle drug delivery system from synthesized biodegradable polymers and modify the polymeric nanoparticles using targeting antibodies for targeted delivery of anticancer drugs. A new biodegradable copolymer poly(2-methyl, 2-carboxy …
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Development of novel polymeric nanoparticles with tailored architectures and functionalities/
… route to a combinatorial library of functional nanoparticles for applications like drug delivery is one of the main interests of our group. To this end, we have envisioned a novel nanoparticle architecture called a brush-arm star polymer (BASP), which has polymer brushes on the periphery …
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… dry powder vaccine formulation containing polymeric nanoparticles (NPs) adsorbed with PspA4Pro and formulated into nanocomposite microparticles (NCMPs) using L-leucine (L-leu) to be delivered via inhalation was developed. Poly(glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL, NPs with …
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Self-assembling polymeric nanoparticles for enhanced intra-articular anti-inflammatory protein delivery
The goal of this thesis was to develop a new drug-delivering material to deliver anti-inflammatory protein for treating OA. Our central hypothesis for this work is that a controlled release/presentation system will more effectively deliver anti-inflammatory protein therapies to the OA joint. The …
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Biocompatible polymeric nanoparticles for drug/DNA delivery using biologically friendly polymerisation processes
… explores the synthesis of several different polymeric nanostructures using reversible addition-fragmentation chain transfer (RAFT) polymerisation in both aqueous and ethanolic solutions.<br/><br/>A preface entailing an abstract, contents, common abbreviations and details of where this work …
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Prominent Platforms for the Synthesis of Size-Controllable Polymeric Nanoparticles for Gene Delivery
… during delivery poses a critical challenge. The polymeric nanoparticles (PNPs), as an appealing approach for safeguard- ing genetic material, present benefits such as a high payload, stable colloidal and storage stability, and versabtile functionalization.This study focuses on the development of …
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Design and development of polymeric nanoparticles by continuous manufacture using twin screw extrusion
Nanoparticles have received significant attention due to their vast potential to treat a plethora of diseases. There is much interest and innovation within the field with the global market value of nanotherapeutics projected to be worth US$369.5 Billion by 2027 (Research and Market, 2020). Despite …
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Poly(LA-co-TMCC)-graft-PEG Self-assembled Polymeric Nanoparticles for Targeted Drug Delivery
Polymeric nanoparticles have gained increased popularity for drug delivery as they not only overcome the problem of limited aqueous solubility of many hydrophobic drug molecules, but also have the potential to improve the pharmacologic properties of anticancer drugs by increasing their in vivo …
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Synthesis and evaluation of pyrazinoic acid loaded polymeric nanoparticles in the treatment of Tuberculosis
… and overall therapeutic effect. We propose a polymeric nanoparticle (NP) based system to deliver POA. The NPs are aimed to deliver POA for a therapeutic effect against mycobacteria. This study therefore investigates the synthesis, characterization and the antimycobacterial activity of such …
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Layer-by-layer assembled multilayers and polymeric nanoparticles for drug delivery in tissue engineering applications
Thesis (Ph. D.)--Michigan State University. Dept. of Materials Science and Engineering, 2010
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A microfluidic platform for combinatorial synthesis and optimization of targeted polymeric nanoparticles for cancer therapy
… A key challenge for optimization of nanoparticles (NPs) for drug delivery is the ability to systematically and combinatorially create and screen libraries of NPs with distinct physicochemical properties, from which promising formulations can be moved forward to preclinical and …
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Development of Polymeric Nanoparticles Containing a Natural Antioxidant (α-Tocopherol) for the Treatment of Spinal Cord Injury
… Thus, this study focuses on developing nanoparticles (NP) loaded with naturally occurring antioxidant α–tocopherol (α–TP) for delivery to the injured site in SCI. Calcium alginate NP (CA–NP) and poly lactic co–glycolic acid (PLGA) NP were prepared by ionotropic gelation and solvent …
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Functional Protein Delivery Using Polymeric Nanoparticles: A Novel Therapeutic Approach to Alpha-Synuclein Aggregation and Parkinson's Disease
… such as Parkinson's disease (PD). Synthetic nanoparticles made from polybutylcyanoacrylate (PBCA) have been previously shown to deliver otherwise impermeable drugs to therapeutic levels in vivo across the blood-brain barrier (BBB). It was not yet known, however, whether such particles could …
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Design and optimization of polymeric nanoparticles for the delivery of a novel computationally designed colchicine derivative for cancer application
L'abstract è presente nell'allegato / the abstract is in the attachment
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Investigation of the absorptive potential of polymeric nanoparticles across the lungs and their development for efficient systemic delivery following pulmonary administration
… drug delivery of small molecules and proteins. Nanoparticles on the other hand have gained increasing interest in drug delivery due to the wide variety of advantages they possess that allow for temporal, spatial and targeted delivery of therapeutics that can be fine tuned for various …
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