Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Polymeric Micelles"”.
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EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors
… of Pc 4 in biocompatible block-copolymer micelles, (2) Modify micelle surface with EGFR-specific ligands and investigate cancer cell targeting of the surface-modified micelles in vitro, and, (3) Investigate targeted PDT effects on SCC cell lines in vitro and suitable animal models in vivo …
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Design of Functional Polymeric Micelles as a Carrier for Anticancer Drug Delivery
Polymeric micellar nanoparticles are frequently utilized as drug delivery carriers due to their particular core/shell structure, ease of functionalization, sustained circulation in the blood and its ability to passively accumulate in leaky tumor tissues. Two important factors that should be …
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Annexin A5-Conjugated Polymeric Micelles For Dual Spect and Optical Detection of Apoptosis
… this study, we developed annexin A5-conjugated polymeric micellar nanoparticles dual-labeled with a near-infrared fluorescence fluorophores (Cy7) and a radioisotope (<sup>111</sup>In), named as <sup>111</sup>In-labeled annexin A5-CCPM. <em>In vitro</em> studies demonstrated that annexin A5-CCPM …
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Cationic Polymers and Polymeric Micelles as Plasmid DNA and CRISPR-Cas9 Ribonucleoprotein Delivery Vehicles
… However, the precise control of polymeric vehicle properties by structure-tuning is a general challenge. Hence, the fundamental understanding of polymeric vehicle’s structure-property relationships is of great importance. In addition, polymers as well-documented nucleic acid …
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The multifarious self-assembly of triblock copolymers : from multi-responsive polymers and multi-compartment micelles
… The second approach towards advanced polymeric micelles exploited the thermodynamic incompatibility of “triphilic” block copolymers – namely polymers bearing a hydrophilic, a lipophilic and a fluorophilic block – as the driving force for self-assembly in water. The self-assembly of …
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Efficient Drug and Nucleic Acid Delivery Systems based on Synthetic Amphiphiles with Tuned Oil/Water Interfaces
… interface-engineered amphiphilic block copolymer micelles that were previously introduced by our lab were assessed for their stability in the presence of various esterase enzymes present in serum and on blood vessel walls, normally encountered by drug delivery systems on route to the targeted …
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Self-assembly of bioactive or electrocatalytic polyaspartamide nanoparticles
… 3); 3) To improve electrocatalytic activities of polymeric micelles via surface coating with platinum nanocubes (Chapter 4). Overall, the results of this thesis study would greatly serve to allow us to engineer the function of nanocarriers in a simple and economic manner, and expedite their uses …
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Design of functional polymeric materials for cancer-targeted drug delivery and cellular capture and isolation
Synthetic polymeric materials offer many exciting advantages with the plethora of functionalization techniques affording materials with unique properties, multiple functionalities, and elaborate architectures for a variety of applications. In the drug delivery field, the use of synthetic polymers …
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High-Frequency Ultrasound Drug Delivery and Cavitation
… drugs (Doxorubicin) in the hydrophobic core of polymeric micelles and triggers release by ultrasound application was investigated at an applied frequency of 500 kHz. The investigation also included elucidating the mechanism of drug release at 70 kHz, a frequency which had previously been shown …
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Bioinspired soft matter self-assembly and its use in biomedical applications
… oil/water mixing rate on the size of nano-sized polymeric micelles and vesicles (Chapter 4). An additional study focuses on a self-assembled cluster of imaging agents for stem cell labeling (Chapter 5). Furthermore, this thesis explored a strategy to significantly increase the bioavailability of …
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Computer-Guided Design of Photocatalyst for PET-RAFT Polymerisation
… such as surface patterning, 3D/4D printing, polymeric micelles, multiblock antimicrobial polymers with precise sequences and architectures. All these unique features of photo-controlled polymerisation are largely dependent on properties and functionalities of PCs. Traditionally, the selection …
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Topical Clear Aqueous Nanomicellar Formulations For Anterior And Posterior Ocular Drug Delivery
… rapamycin were entrapped in the core of polymeric micelles and solubilized. Polymeric amphiphilic molecules (e.g., hydrogenated castor oil – 40 (HCO-40) and Vit. E TPGS) are known to generate nanomicellar constructs with hydrophobic core and hydrophilic corona. However, constructs …
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DEVELOPMENT AND APPLICATION OF MODIFIED HYALURONIC ACID DERIVED NANOPARTICLES FOR IMAGE GUIDED SURGERY AND DRUG DELIVERY
… polymer backbone for the synthesis of nanoscale polymeric micelles loaded with either the near infrared (NIR) fluorophore indocyanine green (ICG) for image guided surgery (IGS), or the fatty acid synthase (FASN) inhibitor Orlistat (ORL) for chemotherapy. Hydrophobic conjugates were synthesized …
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Novel amphiphilic diblock copolymers by RAFT-polymerization, their self-organization and surfactant properties
… The new macro-surfactants form micelles in water, whose size and geometry strongly depend on their composition, according to dynamic and static light scattering measurements. The micellization is shown to be thermodynamically favored, due to the high incompatibility of the blocks …
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Nanotherapies for Treating Prostate Cancer
… for treating prostate cancer and develop polymeric nanocarriers to facilitate anticancer drug and nucleic acid delivery.</p> <p>It was hypothesized that simultaneously targeting androgen-androgen receptor (AR) and X-linked inhibitor of apoptosis protein (XIAP) signaling pathways would be …
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Designing a safe dendronised polymeric nanocarrier for hydrophobic drugs or gene delivery in cancer therapy
… vector system based on peptide dendronised polymeric micelles to enhance the delivery of hydrophobic drugs into liver cancer cells. G3(PLLA and OGPLLL) arginine dendron of third generation bearing eight peripheral hydrophobic or cationic groups (PBF and BOC or guanidine groups) were …
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Polyelectrolyte Complexes and their Therapeutic Potential
… Second, the structure of ionic multicompartment micelles (MCMs) when complexed with polyions was studied and the performance of these nanostructures as delivery agents of anti-cancer drugs both in vitro and in vivo was tested. To better understand structure-property relationships of polycations …
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Impact of Amphiphiles in Cellulase Stabilization, Recycling and Ethanol Production from Pretreated Biomass
… the potential role of novel protein-based micelles and surfactant or protein-based polymeric micelles (PMs) was tested on enzyme activity, hydrolysis, fermentation and enzyme recycling. And the potential mechanisms of action of these amphiphiles and their economical viability were …
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RNA Interference for Improving the Outcome of Islet Transplantation and Polymeric Micelle‑based Nanomedicine for Cancer Therapy
… part of research was focused on the study of polymeric micelle formulations for treating cancers. Two key elements were integrated in my research projects: development of polymeric micelle delivery systems; discovery of new therapeutics for better treatment of cancers.</p> <p>The project …