Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Polymeric Micelle"”.
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RNA Interference for Improving the Outcome of Islet Transplantation and Polymeric Micelle‑based Nanomedicine for Cancer Therapy
… part of research was focused on the study of polymeric micelle formulations for treating cancers. Two key elements were integrated in my research projects: development of polymeric micelle delivery systems; discovery of new therapeutics for better treatment of cancers.</p> <p>The project …
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Stable Polymer Micelle Systems as Anti-cancer Drug Delivery Carriers
<p>Several temporarily stable polymer micelle systems that might be used as ultrasonic-activated drug delivery carriers were synthesized and investigated. These polymeric micelle systems were Plurogel®, Tetronic®, poly(ethylene oxide)-b-poly(N-isopropylacrylamide) and poly(ethylene …
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Paclitaxel nanoparticles for breast cancer therapy in pregnancy
… an albumin nanoparticle; and Genexol-PM, a polymeric micelle. Using the ex vivo dually perfused human placental cotyledon, we were able to show that paclitaxel transfer appears to be similar across the formulations, but the maternal concentrations and placental accumulation varies …
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Synthesis, Properties, and Biology of Advanced H2S-Releasing Materials
… were prepared that self-assembled into micelles or vesicles based on their composition. H2S was released from these polymer assemblies more slowly than from the small molecules and statistical polymers. These H2S-releasing micelles were employed in in vitro cytotoxicity studies. H2S …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… study, I have successfully encapsulated DS into polymeric micelle (PM) nanoparticles. The half-life of PM encapsulated DS (PM-DS) was extended to over 3 hours in horse serum. The PM-DS showed strong anticancer efficacy. Therefore this nano-enabled DS may be able to translate DS into cancer …
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Photocontrol of Antibacterial Activity
… one of the oxime esters was trapped in a polymeric micelle, which highly enhanced this property. Lastly, the sixth chapter also focuses on the caging technique and tries to solve some of the drawbacks that oxime esters present. In this chapter, a new photoreleasable group was employed, …
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Synthesis and study of the micellization behavior of a dual temperature- and pH-responsive PAA-b-PNIPAM block copolymer
… hydrophilic regions outside to give a core-shell micelle. These micelles have many potential applications, such as a drug delivery system, surfactants, or nanoreactor. Many studies have been done to optimize the performance of these copolymers. In this thesis work, nine dual temperature- and …
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Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier
… enzyme-responsive, and targeted polymer micelle for cabazitaxel. The micelle was spontaneously formed from two amphiphilic block copolymers. The first block copolymer consists of PEG, an enzyme-responsive peptide, and cholesterol; whereas the second block copolymer consists of a targeting …