Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Polymerase bypass"”.
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Synthesis and detection of dna damage
… unstable DNA lesions enables accurate study of polymerase bypass. The design and successful synthesis of N7-hydroxyethyl-9-deaza-2'-deoxyguanosine and N7-oxoethyl-9-deaza-2'-deoxyguanosine as the stable analogues of N7-hydroxyethyl- 2'-deoxyguanosine and N7-oxoethyl-2'-deoxyguanosine, …
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Synthetic approaches to the understanding of DNA nucleobase methylation
… products for most methylating agents. DNA polymerase actions on ^{7Me}dG are difficult to study due to its instability against ring- opening hydrolysis and deglycosyl ati on. Oligonucleotides containing a single chemical adduct of ^{7Me}dG cannot be chemically synthesized. In addition, …
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DNA-Protein Cross-links: Formation, Repair, and Inhibition of DNA replication
… the local DNA sequence effects on TLS polymerase bypass of 5fC-mediated DNA-peptide crosslinks. Our previous studies revealed that full size DPCs inhibit DNA replication and transcription but can undergo proteolytic cleavage to produce smaller DNA-peptide conjugates. We have shown that …