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Showing 1 to 2 of 2 for “"Polymerase Discrimination"”.
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The Impact of Nucleoside Sugar Modification on Biochemical DNA Transactions
Discrimination by DNA polymerases controls the fidelity of DNA replication, and reduced fidelity results in mutations essential in the etiology of cancer. Polymerase discrimination operates at both dNTP insertion and subsequent elongation steps, and involves several energetic and structural factors …
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The effect of oxidized guanines on DNA synthesis by DNA polymerase β
… for passing on to a daughter cell. DNA polymerases are the molecular machines that read the parent DNA strand and instruct the addition of correct corresponding nucleotides (also termed fidelity) to form a new DNA strand. DNA replication is extremely accurate to prevent deleterious …