Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Polymer-tethered"”.
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Polymer-tethered epidermal growth factor as an inductive biomaterial surface for connective tissue progenitors
… project entails the design of a two-component polymeric implant system to aid in the healing process of bony defects by influencing cell behaviors at the implant site through the covalent modification of the implant surface with selected ligands. We investigate cellular responses of CTP on a …
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Influence Of Cholesterol And Bilayer Asymmetry On Membrane Protein Distribution In Polymer-Tethered Raft-Mimicking Lipid Membranes
… monolayers with elevated concentration of lipopolymers are able to respond to increasing lateral stress by inducing membrane buckling, a stress relaxation phenomena. As part of the current dissertation, we established that membrane buckling can also be induced by gradually increasing CHOL …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… assembly and distribution are examined in a polymer-tethered lipid bilayer system using comple-mentary confocal optical detection techniques, including 2D confocal imaging and single molecule-sensitive confocal fluorescence intensity analysis methods [fluorescence correlation spectroscopy (FCS) …
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Probing cellular mechano-sensitivity using biomembrane-mimicking cell substrates of adjustable stiffness
… advancements in this field have been made using polymeric substrates of adjustable stiffness with immobilized linkers. While such substrates are well suited to examine cell adhesion and migration in an extracellular matrix environment, they are limited in their ability to replicate the rich …
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PROBING CELLULAR MECHANO-SENSITIVITY USING BIOMEMBRANE-MIMICKING CELL SUBSTRATES OF ADJUSTABLE STIFFNESS
… advancements in this field have been made using polymeric substrates of adjustable stiffness with immobilized linkers. While such substrates are well suited to examine cell adhesion and migration in an extracellular matrix environment, they are limited in their ability to replicate the rich …
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Design of Biomembrane-Mimicking Substrates of Tunable Viscosity to Regulate Cellular Mechanoresponse
… to differentiation. While previous studies on polymeric gels have revealed the influence of substrate elasticity on cellular shape and function, a lack of suitable substrates (i.e. with mobile cell-substrate linkers) has hindered research on the role of substrate viscosity. This work presents …
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Controlling the Properties of Polymer Metal-Organic Frameworks and Cages Through Polymer Ligand Design
Chapter 1: Synthetic and Design Considerations in Polymer Metal Organic Frameworks and Cages Strategies for developing polymer-tethered MOF/MOC hybrid materials are discussed. Emphasis is place on the impacts of synthetic strategy and polymer ligand design on the properties and applications of the …
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Blood clotting inspired polymer physics
… observed in this process within the context of polymer physics. By understanding these physical principles, we hope to harness nature's ability to both direct molecules in both spatial and conformational coordinates. This thesis is presented in three complementary sections. After an initial …