Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Polymer-drug conjugates"”.
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Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes
We have conceptualized a new class of polymer-linker-drug conjugates to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and …
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Design, development, and evaluation of novel polymer-drug conjugates and interpolymer complexes for the treatment of neurodegenerative disease.
… and toxicity, leading to low bioavailability. Polymer-drug conjugates (PDCs) offer a promising strategy by covalently linking bioactive molecules to water-soluble polymer backbones, improving solubility and therapeutic efficacy. This study aimed to develop novel PDCs and their nano-polyplexes …
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Bioengineering functional polymer systems for glycan-based targeting and drug release
Bioengineering drug delivery facilitates re-potentiation of existing drugs and drug candidates, bypassing hurdles in novel drug development and accelerating the advance of medicine. Drug delivery strategies aim to enhance therapeutic effect by enhancing delivery to the target cells or tissues, …
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Development of polymeric drug delivery vehicles for targeted cancer therapy
… to generalize a method for targeted anti-cancer drug delivery. Hydrophilic polymer-drug conjugates involve complicated synthesis; drug-encapsulated polymeric nanoparticles limit the loading capability of payloads. This thesis introduces the concept of nanoconjugates to overcome difficulties in …
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Design of Novel Antigen-Specific Immunotherapies for the Treatment of Autoimmune Disorders
… development of a new therapeutic class, antigen-drug conjugates (AgDCs). By reversing the paradigm of antibody-drug conjugates (ADCs), AgDCs exploit the directing effect of the autoantigen towards diseased cell populations, coupled with the immunomodulatory effects of a small molecule drug. …
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TOOLS AND STRATEGIES FOR THE SYNTHESIS OF PHARMACEUTICAL ACTIVE COMPOUNDS
… as a green starting material to create novel drug-containing macromolecules for future drug-delivery applications, outlined in Chapter 4. In the final part of my Ph.D. program, I moved to Indena SpA (Settala, Italy) to complete my industrial internship, which was a part of my Ph.D. funding. …