Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Polyketide synthases (PKS)"”.
-
The Role of the Alternaria Secondary Metabolite Alternariol in Inflammation
… metabolites that are synthesized by genes called polyketide synthases (PKS) in immune responses of lung epithelial cells.
-
Cyclization modes in type III polyketide synthases and the synthetic compounds used as probes for mechanistic studies.
Type III polyketide synthases (PKS) catalyze different cyclization reactions of linear polyketide intermediates to produce polyketides with distinct ring structures. The mechanisms of pyrone and resorcinol ring formation in type III PKSs remain unknown, despite many years of research on this family …
-
Characterisation of microbial Mat communities in meltwater ponds of the McMurdo ice shelf, Antarctica
… non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) genes were identified which could be the genetic basis for novel bioactives. The use of a multi-disciplinary approach synthesis and subsequent results significantly increased our understanding of the diversity and function …
-
Analysis of the diverse antibacterial strategies used by <i>Serratia marcescens</i> Db10
… peptide synthetases (NRPS) and polyketide synthases (PKS) are widespread in bacteria and fungi and are responsible for the biosynthesis of many metabolites with medically relevant properties, including antibiotics. The activity of NRPS and PKS enzymes is dependent on their …
-
Characterisation of Epicoccum spp. secondary metabolism genes through de novo genome and transcriptome sequencing
… the genome, including eight clusters containing polyketide synthases (PKS), which were predicted to be required for epipyrone biosynthesis. Protocols for epipyrone production by submerged fermentation of Epicoccum were optimised to compare two conditions that strongly differ by level of epipyrone …
-
Discovering novel natural products from bioactive plants and bacteria
… One group of valuable natural products is polyketides, which are known to be antiviral, antibacterial, and anticancer. In my first project, I attempted to develop an efficient strategy for cloning and characterizing Type III PKS genes that are likely responsible for the synthesis of novel …