Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 144 for “"Polygenic"”.
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Monogenic, multigenic, and polygenic determinants of cancer risk
… possibilities: monogenic, multigenic, and polygenic, are provided. It is expected that technology will be developed to identify and enumerate rare inherited alleles in large general and cancer proband populations.
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Polygenic association in ADHD for the prediction of cognitive performance
… Using the same sample we now evaluate whether polygenic signals for ADHD generated from genome-wide SNP data are associated with the most promising cognitive variables. Analysis used data from the International Multi-Centre ADHD Gene (IMAGE) project. Transmission disequilibrium test (TDT) was …
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Leveraging genotypes imputation and polygenic risk scores in malaria susceptibility
… of an individual as a risk predictor using Polygenic Risk Scores (PRS). However, imputation remains at modest in Africa populations with few (or no) studies (study) have evaluated the potential of imputation tools in African populations. On the other hand, although the utility of PRS has …
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Private Random Variate Sampling for Secure and Federated Polygenic Risk Scores
Polygenic risk scores (PRS) are used to quantify the additive effect of single nucleotide polymorphisms (SNPs) on an individual’s genetic risk for developing a particular trait or condition. Collaborations between data centers are important for improving the statistical power and validity of PRS …
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Estimation of Variance Components in Finite Polygenic Models and Complex Pedigrees
… basis for increased genetic progress. The finite polygenic model (FPM), which contains a finite number of unlinked polygenic loci, is proposed as an improvement to the infinitesimal model (IM) for estimating both additive and dominance variance for a wide range of genetic models. Analysis under an …
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Improving Clinical Risk Models through Integration of Polygenic Risk Scores and Omics
… application to disease research. Methods such as polygenic risk score analysis have been presented to enhance disease risk prediction, however, the clinical utility of these methods are controversial. Similarly, the identification of genes associated with likely causal SNPs is unclear as …
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Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility
… a novel rat model with high relevance to the polygenic development of obesity and breast cancer in humans. These rats have differing susceptibility to obesity when fed a diet of similar macronutrient composition as that consumed by the average American woman. Diet susceptible (DS) rats rapidly …
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Risk Prediction and Value of Polygenic Risk Scores in Colorectal Cancer Screening
… are based on common genetic variants, known as Polygenic risk Score (PRS), have shown promises to guide personalized screening for colorectal cancer (CRC). Continuous efforts to improve PRS risk prediction are needed for clinical use, and understanding its added value of guiding CRC screening is …
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Integrating bioinformatics and physiology to describe genetic effects in complex polygenic diseases
Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. This thesis has focused on dissecting the …
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Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective
… technologies, gene therapies to prevent polygenic diseases may soon become possible. This research assesses the population genetic consequences of such therapies. This research commenced by quantifying the risk of polygenic late-onset diseases. Computer simulations of population age …
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Biomarker-And Pathway-Informed Polygenic Risk Scores for Alzheimer's Disease and Related Disorders
… contribute a small portion of the overall risk. Polygenic Risk Scores (PRS) are a mathematical construct or composite that aggregates the small effects of multiple variants into a single score. Potential applications of PRS include risk stratification, biomarker discovery and increased prognostic …
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Genome-wide polygenic scores, executive function, and attention-deficit/hyperactivity disorder in youth
… was to clarify associations among genome-wide polygenic scores, executive functions, and ADHD in a subsample of 4,226 youth to determine whether executive dysfunctions mediate the relationship between cumulative genetic risk and a dimensional trait measure of ADHD. Polygenic scores derived from …
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DISSECTING THE POLYGENIC LANDSCAPE OF HUMAN COMPLEX TRAITS AND DISEASES IN A SOUTHERN ITALIAN COHORT
… locus. We then assessed the transferability of polygenic scores derived from Northern European datasets to the Italian context, finding that predictive accuracy was reduced for several traits. However, incorporating variants specific to the Italian population improved performance in some cases, …
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Role of Genotype-by-Temperature Interactions in the Maintenance of Polygenic Sex Determination in the House Fly
… that segregate independently, resulting in polygenic sex determination. Most population genetics models predict that polygenic sex determination will be an unstable intermediate between monogenic systems, and the factors responsible for maintaining polygenic sex determination are poorly …
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GENETIC CHARACTERIZATION OF THE ST. KITTS-ORIGIN VERVET MONKEY (CHLOROCEBUS AETHIOPS SSP.) AS A MODEL OF POLYGENIC OBESITY
… vervet monkey as a nonhuman primate (NHP) of polygenic obesity, the human ortholog vervet TNF gene and flanking regions were sequenced and genotyped from 265 monkeys in a closed, pedigreed colony. This revealed a total of 11 single nucleotide polymorphisms (SNPs), and one 4 base pair …
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A Genome-wide Association Study of Schizophrenia in the South African Xhosa and Generalizability of Polygenic Risk Score across African populations
… populations. Thus, the prediction accuracy of polygenic risk scores (PRS) derived from EUR ancestry populations is less accurate in populations of non-European ancestry, and least accurate in African (AFR) ancestry populations. The extent to which PRS prediction accuracy varies within AFR …
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Functional Genome-wide Association Studies (fGWAS) and genomics landscape of signatures of polygenic adaptation in Botswana populations with HIV-1 C infection
… the genomics landscape of signatures of polygenic adaptation to the HIV-1C in Botswana using genomewide scans for selection (GWSS). For the first goal, we looked at several HIV-related studies that had been done in Botswana from 1995 to 2020. We saw significant advancements in the fight …
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Polygene Scores für häufige komplexe Erkrankungen und deren Anwendung auf Parkinson
… dem Titel „Validity and Prognostic Value of a Polygenic Risk Score for Parkinson’s Disease“ behandelt die Validierung eines veröffentlichten PGS für PD und untersucht, ob die prognostischen Fähigkeiten dieses PGS isoliert sinnvoll für die Versorgung von Patientinnen und Patienten genutzt werden …
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Understanding low-penetrance genetic risk for breast cancer
… as part of the MassARRAY® System by Sequenom®. Polygenic risk across 18 loci was found to follow a log-normal distribution with a mean close to zero in the Scottish population, with higher means for those with a family history and for those with breast cancer. The discriminatory accuracy of the …
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