Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Polyethylenimine"”.
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CO2 Adsorption on Polyethylenimine-Impregnated Lamellar Silica
The increasingly stringent environmental regulations worldwide demand the use of efficient methods for air purification. Moreover, the alarming effect of greenhouse gases on the world climate requires the removal and sequestration of large quantities of anthropogenic carbon dioxide (CO2). This work …
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FLUORESCENT PROBE INVESTIGATIONS OF MICROENVIRONMENTS OF ANALYTICAL INTEREST (REVERSED-PHASE, POLYETHYLENIMINE, POLARIZATION)
… using a three component system: metals bound to polyethylenimine (PEI) and pyrenesulfonate counterion probes. Metals altered rates of excited state processes and defined binding environment. Variables were net charge on metal and probe and metal-amine complex properties. Cu(II)-PEI efficiently …
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Elucidation of Design Criteria for siRNA Delivery in Mammalian Cells Using Polyethylenimine
The research presented in this thesis addresses the issue of how PEI concentration affects siRNA delivery efficiency. It also examines how PEI derivatives affect the three primary in vitro barriers: (1) cellular uptake, (2) endosomal escape, and (3) unpackaging of PEI/siRNA polyplexes. Chapter 2 …
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Specific and efficient in vivo delivery of DNA and siRNA by polyethylenimine and its derivatives
Linear polyethylenimine (PEI) is the "gold standard" of polycationic gene delivery vectors. However, little focus has been placed on enhancing or understanding the specificity of PEImediated gene delivery. Herein we evaluated the effect of chemical modification on the specificity of PEI-mediated …
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The effects of PVP(FE(III)) catalyst and polymer molecular weight on gene delivery via biodegradable crosslinked polyethylenimine
… Our group has previously reported biodegradable polyethylenimines (PEI) that show high transfection efficiency and low toxicity by cross-linking 800 Da PEI with diacrylate cross-linkers using Michael addition. However, the synthesis was difficult to control, inconsistent, and resulted in polymers …
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Polymeric nanocarriers with dendritic core-shell architectures
Hyperbranched polymers, polyglycerol and polyethylenimine, were functionalised in order to tailor systems that can be used in medical applications. The systems described in this thesis can be used for pH controlled release of drug molecules and were also investigated towards their gene transfection …
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Engineering the microfabrication of layer-by-layer polyelectrolyte assembly
… Weak polyelectrolytes such as linear (polyethylenimine) (LPEI), branched (polyethylenimine) (BPEI), poly(allylamine hydrochloride (PAH), poly(acrylic acid) (PAA) and poly(methacrylic acid) (PMAA) were adsorbed at pH 2.5. 4.8, 7, and IO on patterned COOH and EG SAMs to determine optimal …
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Engineering scaffold and soluble cues for cell-instruction
… and metastable poly(ethylene glycol diacrylate)-polyethylenimine hydrogels for the release of cytokines in vivo (chapter 7). The high stiffness of the material, attained from the highly branched architecture of polyethylenimine, allowed the hydrogel to release encapsulated substances independent …
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Syntheses, structures and properties of novel poly(amino ester)s
… efficiency for DNA delivery comparable to polyethylenimine (PEI). Furthermore, some hyperbranched poly(amino ester)s can emit blue fluorescence. These poly(amino ester)s should be applicable for safe and efficient gene and drug delivery and as novel biocompatible fluorophores.
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Targeting the myofibroblast : new strategies in managing equine corneal fibrosis
… growth factor beta. Our results indicate that polyethylenimine nanoparticle therapy is safe and effective and when delivering decorin, a natural antagonist of transforming growth factor beta, fibrosis is significantly inhibited in vitro. Additionally the histone deacytelase inhibitor …
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Targeting and Reprogramming Tumor-Associated Macrophages with Polymeric Nanoparticle-Mediated mRNA Delivery for Cancer Treatment
… designed a PNP that consists of perfluorinated polyethylenimine (PFHA-PEI), polyethylene glycol and polyethylenimine (PEG-PEI) and heparin (LHP), which can endow nanoparticles with biocompatibility and membrane penetration ability, facilitating the entry of genetic material into cells. The …
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Hybride von Metall-Nanopartikeln mit hochverzweigten Polyethylenimin als lösliche, abtrennbare Katalysatoren
… metal particles with hyperbranched amphiphilic polyethylenimine. Amphiphilic polyethylenimine-amides with a hyperbranched polyamine core and an apolar lypophilic alkyl chain periphery were obtained by amidation of PEI with carboxylic acids. With carbonyldiimidazole activated acids, the primary …
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Elucidation of Design Criteria for Non-Viral Gene Delivery Vector Development
… DNA and the polymeric gene delivery agent polyethylenimine (PEI). The results indicate that weakened polymer/DNA interactions increase gene delivery efficiency and, more generally, that the strength of polymer/DNA interactions needs to be considered and optimized when designing non-viral …
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Adhesion of silver nanoparticle amendments to ceramic water filters
… polyvinylpyrrolidone (PVP), and branched polyethylenimine (BPEI). Laboratory and field- scale filtration experiments were also conducted to evaluate the removal of Ag NPs from ceramics under different water conditions -- the presence of hardness and natural organic matter (NOM). …
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Investigation of barriers to non-viral gene delivery and design of novel polymer-based gene delivery systems
… we investigated the gene transfer properties of polyethylenimine (PEI), a highly effective non-viral vector material. We demonstrated that the transfection efficiency of this polymer is due to its ability to avoid lysosomal degradation as a result of its buffering capacity, providing quantitative …
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Enhanced polymeric nanoparticles for gene delivery
… standard" for polymeric transfection, 25 kDa polyethylenimine, the PBAE nanoparticles presented here have 100x higher efficacy while simultaneously having 100x lower toxicity. Small structural changes were found to have dramatic effects on multiple steps of gene delivery including the DNA …
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Investigation of microbicidal activity of surface-immobilized hydrophobic polycations
… The resultant, covalently-immobilized, Nalkyl polyethylenimine (PEI) demonstrates complete bactericidal activity against S. aureus and E. coli (i.e., representative Gram-positive and Gram-negative bacteria, respectively). In addition, by utilizing light to activate the covalent cross-linking, …
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Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles
… the buffering capacity to endosomal release of polyethylenimine (PEI) based polyplexes, which could contribute to high transfection efficiency. Secondary amine structures rendered PGAAs buffering capacity around physiological pH. To test the feasibility of the mechanism for PGAAs, new no …
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Plastic Waste-Derived CO2 Sorbents and Methods for Enhanced Selectivity and Stability
… sorbents, an amine-containing polymer, polyethylenimine (PEI), was added to the carbon sorbent in Chapter 4. To do this, we first modulated the pore structure of the sorbent to become more mesoporous through a liquid-salt templating mechanism. More mesoporosity allowed better …
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