Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Polyelectrolyte Multilayer"”.
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Rheology of polyelectrolyte multilayer modified suspension
… and cost effective production. Self-assembled polyelectrolyte multilayer modified colloids are a relatively new and promising colloidal system that is expected to overcome the previousmentioned drawbacks of the established systems. For the first time, this thesis explores themicro-macro …
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Tribological and mechanical characterizations of polyelectrolyte multilayer nanoassemblies
… layer-by-layer assembly of oppositely charged polyelectrolytes has received much interest for the deposition of film architectures, ranging from tens to hundreds of nanometers in thickness, that can be precisely tuned as a function of the processing conditions. The resulting polyelectrolyte …
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Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions
This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer (LbL) deposition platform was used to fabricate conformal, tunable, micron scale …
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Integration of freestanding polyelectrolyte multilayer membranes in larger scale structures
… Promising candidates for such membranes are polyelectrolyte multilayers, which were found to be mechanically stable, and variable in functionality. In this thesis two concepts to integrate such membranes in larger scale structures were developed. The first is based on the directed adhesion of …
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Strategies for incorporating functional block copolymers into polyelectrolyte multilayer coatings
… of temperature (T) responsive block copolymer - polyelectrolyte multilayers (PEMs). First, the LbL conditions that allow for temperature driven, large, reversible swelling transitions of multilayer constructs are determined. Use of weak polyelectrolyte components and selection of an appropriate …
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Polyelectrolyte multilayer thin films with antimicrobial, antifouling and drug releasing properties
This thesis work focuses on designing thin polyelectrolyte multilayer (PEM) films via layer-bylayer (LbL) deposition technique with the ability to kill pathogenic bacteria and inactivate human viruses, especially the influenza (flu) virus on contact. This work builds on four years of research at …
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Light emitting characteristics and dielectric properties of polyelectrolyte multilayer thin films
… sequential adsorption technique to deposit thin polyelectrolyte multilayer films. This involves alternately dipping a substrate into dilute aqueous solutions of a positively charged polyelectrolyte followed by a negatively charged polyelectrolyte, with a rinsing step in between. By repeating this …
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Fundamental studies of polyelectrolyte multilayer films : optical, mechanical, and lithographic property control
Polyelectrolyte multilayers (PEMs) are a versatile type of thin film that is created via layer-by-layer assembly of positively and negatively charged polymers from aqueous solutions. Precise control of the PEM thickness, chemical functionality, and molecular architecture is made possible by …
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Evaluation of polyelectrolyte multilayer thin-film coated microneedle arrays for transcutaneous vaccine delivery
… the Irvine and Hammond groups have developed a polyelectrolyte multilayer thin film-coated microneedle platform that can achieve simultaneous DNA and nanoparticle delivery. This delivery platform has the advantage of direct delivery of DNA or polymer nanoparticles to immune-active cells at the …
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Introduction of a thermo-sensitive non-polar species into polyelectrolyte multilayer capsules for drug delivery
The layer-by-layer assembly (LBL) of polyelectrolytes has been extensively studied for the preparation of ultrathin films due to the versatility of the build-up process. The control of the permeability of these layers is particularly important as there are potential drug delivery applications. …
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Optimizing cellular attachment and function in long-term hepatocyte cultures using polyelectrolyte multilayer surface modification
… We employ a unique substrate material system of polyelectrolyte multilayers (PEM) that can be tuned to achieve mechanical compliances of several orders of magnitudes (Es = 105 to Es = 108 Pa). We have shown that PEM modification can effectively change the surface mechanical compliance, and, thus, …
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Study of the effect of mechanical stiffness substrata, assembled with polyelectrolyte multilayer thin films, on biofilm forming staphylococcus epidermidis' initial adhesion mechanism
Polyelectrolyte multilayer thin films are polymer films assembled through a layer-by-layer sequential addition of oppositely charged polymers. The layer-by-layer film assembly technique allows for properties such as film thickness, chemical functionality, and elastic moduli to be easily altered by …
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A platelet-mediated paradigm for the targeted delivery of microencapsulated, clot-augmenting biotherapeutics
… targeted drug delivery system utilizes polyelectrolyte multilayer capsules that hybridize with the patient’s own platelets upon intravenous administration and rupture upon platelet contraction, enabling the targeted and controlled “burst” release of an encapsulated biotherapeutics. As …
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Antibacterial calcite created with a multilayer polyelectrolyte coating method
… the mineral particles are coated with selected polyelectrolytes. A multilayer approach is employed to increase the coverage of the calcite surfaces and slow-down mineral dissolution. The polyelectrolyte multilayer significantly decreases the dissolution of the calcite, so the overall particle …
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Static and ultrafast optical properties of nanolayered composites : gold nanoparticles embedded in polyelectrolytes
In the course of this thesis gold nanoparticle/polyelectrolyte multilayer structures were prepared, characterized, and investigated according to their static and ultrafast optical properties. Using the dip-coating or spin-coating layer-by-layer deposition method, gold-nanoparticle layers were …
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New polymeric biomaterial interfaces for biosensor applications
… bio-functionality with patternability on charged polyelectrolyte multilayer surfaces. Polymer-on-polymer stamping (POPS) techniques were used to create micron scale patterned regions on negatively charged multilayer surfaces via direct stamping of these graft copolymers. The long PEG side chains …
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Polyelectrolyte multilayers incorporating photocrosslinking polymers for controlling 2- and 3-dimensional structure
Polyelectrolyte multilayer (PEM) assembly is a technology for building thin films with a number of useful and novel functionalities. PEMs interact favorably with proteins and other biomolecules making them potentially valuable as biomaterials. Many systems of polymers have been studied for use in …
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Assembly and post-assembly manipulation of polyelectrolyte multilayers for control of bacterial attachment and viability
… thesis was to exploit the versatility of the polyelectrolyte multilayer (PEM) platform to consider bacteria-substrata interactions by varying multilayer assembly and post-assembly conditions. We developed multiple PEM systems to probe the ability of substrata to resist bacteria attachment or …
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Direct Force Measurements on the Colloidal Scale: From Modified Electrodes to Particle Manipulation
… (AFM). Additionally, the elastic properties of polyelectrolyte multilayer films were locally resolved under controlled humidity. The adhesive behaviour of colloidal particles on modified electrodes has been studied by direct force measurements with a micrometre-sized silica probe attached to an …
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