Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Polycythemia vera"”.
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Determinants of clinical phenotype in myeloproliferative neoplasms
… Myeloproliferative neoplasms, (MPNs) such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates. The genomic characterization of patients with myeloproliferative neoplasms offers the potential for personalized …
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Implementation of the JAK2V617F mutation analysis in the pathway of suspected myeloproliferative neoplasms in Groote Schuur Hospital
… In 120/297 patients MPN was confirmed: Polycythemia vera (PV), (n=51, 100% JAK2 mutated); essential thrombocytosis, (n=41, 42% JAK2 mutated); primary myelofibrosis (n=28, 57% JAK2 mutated). The 2016 WHO haemoglobin/haematocrit thresholds in PV were validated. Idiopathic erythrocytosis …
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Inferring Clonal Dynamics in Blood using Single-Cell Measurements
… disease forms—essential thrombocythemia (ET), polycythemia vera (PV), or primary myelofibrosis (PMF)—and the reason for this variation remains unknown. One compelling hypothesis is that the JAK2-V617F mutation may arise in HSC subsets with intrinsic biases toward platlet-producing cells (as in …
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Signaltransduktion durch JAK/STAT-Moleküle bei der Polyzythämia vera
Polyzythämia vera gehört zu den Erkrankungen des myeloproliferativen Formenkreises. Die Ursache wird in einer veränderten hämtapoetischen Stammzelle vermutet. Auffällig ist eine Hypersensitivität der Vorläuferzellen auf diverse Wachstumsfaktoren. Diese Hypersensitivität und möglicherweise die …