Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Polycythaemia vera"”.
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
… comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling pathway molecules and a variable tendency to develop acute myeloid leukaemia (AML). This …
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Untersuchung von PRV-1 auf Protein-Protein-Interaktions-partner im Yeast-Two-Hybrid Assay und weitere Aufklärung der 5'cDNA-Sequenz einer potentiellen Tyrosinkinase
… molekularbiologischen Ursache der Erkrankung "Polycythaemia vera" wurden mehrere Kandidatengene in einem Screening-Verfahren (Subtraktive Hybridisierung) gefunden. In dieser Arbeit wurden zwei dieser Kandidatengene, PRV-1 (Projekt I) und AB3 (Projekt II), näher untersucht. <br>Um Aussagen über …
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The molecular pathogenesis of myeloproliferative neoplasms
… finding that approximately 95% of cases with<br/>polycythaemia vera (PV) and 50-60% of cases of essential thrombocythaemia (ET) and primary<br/>myelofibrosis (PMF) are characterised by a single acquired mutation, JAK2 V617F. My study has<br/>focused on four principal areas:<br/><br/>(i) …
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Detection of the calreticulin type 1 and type 2 mutations in a group of myeloproliferative neoplasm patients using molecular methods
… the Philadelphia (Ph) chromosome-negative MPNs: polycythaemia vera (PV), essential thrombocythaemia (ET) and primary myelofibrosis (PMF) or myelofibrosis (MF). In 2013, somatic mutations at exon 9 of CALR, the gene that encodes for calreticulin, were discovered through whole-exome sequencing and …
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Gene expression profiling of patients with Polycythaemia Rubra Vera using cDNA microarrays
In this work, several attempts to elucidate the physiological role of the murine PRV-1 gene by whole mount in-situ hybridisation experiments did not yield reproducible results. Nevertheless, expression of the mPRV-1 mRNA could be demonstrated from embryonic day 6.5 on by RT-PCR experiments. In …
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Screening auf Interaktionspartner für den hämatologischen Rezeptor PRV-1 : PRV-1 interagiert mit Decorin, C1qB und Defensin alpha 3
Die Polycythaemia Rubra Vera (=PV) ist eine klonale Stammzellerkrankung des hämatologischen Systems. PRV-1 (=Polyzythämia Rubra Vera-1) ist ein hämatologischer Oberflächenrezeptor, dessen mRNA in den Granulozyten von nahezu allen PV Patienten, sowie bei einigen Patienten mit Osteomyelofibrose, mit …