Global ETD Search
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Showing 1 to 5 of 5 for “"Polycomb group proteins"”.
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Unbalancing Polycomb group proteins activities during liver homeostasis and tumour formation
… Inactivating mutations of members of the polycomb complexes have been found in a subset of aggressive HCCs, mainly affecting women, and in more than 20% of CCA. To clarify the role of these chromatin-associated complexes in liver homeostasis, we used a comprehensive approach taking …
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EPIGENETIC MECHANISMS OF POLYCOMB REPRESSIVE COMPLEX 1 IN INTESTINAL LINEAGE COMMITMENT
Polycomb group proteins are key transcriptional repressive complexes involved in cell fate decisions during development and cell identity maintenance during homeostasis (1). Polycomb group proteins primarily assemble into two different complexes: Polycomb repressive complex 2 (PRC2) with the …
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Role of Polycomb Group Protein Mel18 in Hematopoietic Stem Cell Maintenance
Polycomb group (PcG) proteins are epigenetic gene silencers that have been implicated in stem cell maintenance and cancer development. Genetic and biochemical studies indicate that Polycomb group proteins exist in at least two protein complexes, Polycomb repressive complex 2 (PRC2) and Polycomb …
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
Polycomb repressive complex 2 (PRC2) catalyses the methylation of ‘Lys-27’ of histone H3, leading to transcriptional repression of target genes through its catalytic subunit Enhancer of zeste homolog 1/2 (EZH1/2). PRC2 functions as a critical regulator of stem cells in mouse embryonic and adult …