Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Polybasic domain"”.
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Reconstitution Of Rho Gtpase Interactions At The Membrane
… a cluster of positive-charged residues (i.e. a 'polybasic domain'), directly preceding their geranylgeranyl moiety. It has been suggested that this domain serves to fine-tune their localization among different cellular membranes. I have used reconstituted systems to examine the role of the …
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Nanoscale Organization of The Small Gtpase Rac1
… palmitoyl, and a polybasic domain (PBD) of contiguous lysine and arginine residues. Using high-resolution imaging combined with spatial mapping analysis, I found that Rac1 forms nanoclusters on the PM. Cycling between the GTP- and GDP-bound states, Rac1 forms …
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Localization and Function of Bacterial Type III and IV Effector Proteins
… enzymes with modular protein interaction domains and subcellular localization motifs. These sophisticated regulatory mechanisms are crucial to the fidelity and efficacy of information relay in both space and time. Bacterial effector proteins are virulence factors that are directly secreted …
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The Role of ERp57 in Hras Intracellular Trafficking and Function.
… has shown that lipid and non-lipid modified domains participate in Ras traffic and that plasma membrane association is mediated by vectorial vesicular transport from the endomembrane system. ERp57, an ER chaperone, has been shown to specifically bind farnesylated Hras but not non-farnesylated …