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Showing 1 to 20 of 89 for “"Polyamines"”.
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POLYCYCLIC POLYAMINES: SYNTHESIS AND CONFORMATIONAL ANALYSIS
<p>The synthesis, conformational analysis, and reactivity of a homologous series of tricyclic orthoamides is discussed. The tricyclic orthoformamides, orthoacetamides, orthopropionamides, and orthobenzamides were synthesized by the uncatalyzed condensation of macrocyclic triamines with amide …
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Macrocyclic Polyamines and Their Metal Complexes Targeting HIV-1
M40401 is a well known antioxidant and as of late, it has been studied for anti- HIV properties. It was reported to reduce apoptosis of astrocytes caused by HIV- 1 infected macrophages (M/M) supernatants, and in 2005, a poster presented at the International Conference for Antiviral Research claimed …
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Method development for analysis of polyamines and metabolites by mass spectrometry
… and DAH, it is expected to work for natural polyamines and their acetylated metabolites.</p> <p>Qualitative analysis was performed by both positive electrospray (ES)- and APCIMS under full mass range scanning. The mass spectra of polyamine standards were characterized. HMBA exhibited an …
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Assessing the Role of Dietary Polyamines on the Continuum of Colorectal Carcinoma
Putrescine, spermidine and spermine are the polyamines biosynthesized by human cells via ornithine decarboxylase (ODC) and are also sourced from the diet. Polyamines are required for malignant and normal cell growth and development. Pharmacological suppression of polyamine biosynthesis, by …
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THE REGULATION OF POLYAMINES AND THEIR ROLE IN THE PROLIFERATION OF HELA CELLS
… cells by the addition of exogenous diamines or polyamines. Intracellular putrescine was eliminated, intracellular spermidine and spermine were severely decreased and proliferation of HeLa cells was inhibited when cultures were maintained for 48 h. in the presence of the non-physiological inducer …
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The Role of Polyamines in Osmotic Stress Tolerance in Gulf Killifish Fundulus Grandis
Polyamines are a diverse class of aliphatic molecules that are highly polycationic at physiological intracellular pH. Polyamine levels are regulated by the coordinated actions of arginase (Arg), ornithine decarboxylase (Odc), and polyamine oxidase (Pao). Although little is known of their functions …
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Floral initiation in <i>Rudbeckia hirta</i>: limited inductive photoperiod, polyamines and cytokinins
… on the number of inductive LD received. Polyamines have been linked to floral initiation and, in this study, were strongly correlated to the stage of floral initiation. As initiation progressed, the observed increases in putrescine and spermidine were followed by a decrease after 16 LD, …
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Synthesis of Macrocyclic Polyamines and their Cu, Fe, Mn and Zn Complexes Targeting HIV (AIDS).
Macrocyclic polyamines cyclotriazadisulfonamide (CADA) and bicyclam AMD3100 act as entry inhibitors against HIV by different mechanisms. The manganese complex of pyridine-fused macrocyclic polyamine (M40401) has been found to reduce HIV-1 induced apoptosis of astroglial cells. Based on these …
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Étude de la réactivité du diépoxyde de limonène lors de sa réticulation par des polyamines
Les époxys sont des matériaux polymériques fréquemment rencontrés dans diverses industries comme la construction l'automobile, l'aéronautique ou l'électronique. Parmi ces époxys, les plus utilisés dérivent de composés tels que le bisphénol A, et l'épichlorohydrine, tous deux avérés toxiques, et …
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Characterization of molecular functions of polyamines in fruit development and ripening in tomato (Solanum lycopersicum)
… (SPD) and spermine (SPM) are three major polyamines (PAs) present in all living organisms. These biogenic amines have been implicated in diverse plant growth and development processes, including seed germination, tissue lignification, organogenesis, flowering, pollination, embryogenesis, …
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Characterization of molecular functions of polyamines in fruit development and ripening in tomato (Solanum lycopersicum)
… (SPD) and spermine (SPM) are three major polyamines (PAs) present in all living organisms. These biogenic amines have been implicated in diverse plant growth and development processes, including seed germination, tissue lignification, organogenesis, flowering, pollination, embryogenesis, …
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The potential antioxidant and anticancer properties of polyamines and their response to high-intensity ultrasonication
Polyamines are widespread in living cells and play several important roles in both plants and animals. The polyamines spermine, spermidine and putrescine have been of primary interest, as they participate in cell growth and proliferation and thus are involved in health, disease and aging. …
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Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
… aims at investigating mechanistic roles of polyamines and microvesicles in tumor biology and hypoxia-mediated angiogenesis. We considered the option of inhibiting cancer cell proliferation by the combination of polyamine synthesis inhibition with phage display-derived antibodies targeting …
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RNA G-quadruplexes and polyamines effects on translation: data analysis and development of software for ribosome pause prediction
… e.g. concentrations of metabolites such as polyamines. G-quadruplexes is a type of RNA secondary structures that has been implicated in mRNA translation. These G-quadruplex structures have been suggested to play roles in capdependent, cap-independent and repeat associated non-AUG (RAN) …
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Comparison of the effect of acetylated polyamines and N⁸-acetylspermidine deacetylase inhibitor, APAH, on LS180 and multidrug resistant cells
… In this study, we investigated the effects ofpolyamines, acetylated polyamines and APAH, a polyamine deacetylase inhibitor, on LS180 cells and the derived MDR LS180 Ad-50 cells. L.ethal concentrations for 20% of the cells (LC<sub>20</sub>) for N<sup>8</sup> -acetylspermidine (N<sup>8</sup> - …
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The synthesis of biologically active oxa-polyamine analogues, homologues and conjugates.
Polyamines such as putrescine, spermidine, and spermine and their derivatives are found to be present in every living cell. Being products of amino acid metabolism polyamines play an important role in normal cell function and replication. Analogues, homologues, and derivatives of natural polyamines …
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On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.
… thesis was to study the hypoxic regulation of polyamines and tumour cell-derived microvesicles (MVs), both of which have been associated with tumour development. It was initially demonstrated that epitope-specific interference of cell surface heparan sulphate proteoglycans (HSPGs) by anti-HS …
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