Global ETD Search
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Showing 1 to 3 of 3 for “"Polyamine pathway"”.
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Engineering and characterization of single chain antibody fragments (scFvs) specific to key enzymes in polyamine biosynthesis and manipulation of polyamine pathway by constitutive expression of recombinant ODC and SDE enzymes in transgenic tobacco
Polyamines are ubiquitous low-molecular weight polycationic compounds found in all living organisms and involved in crucial developmental, physiological and metabolic processes. The majority of information available about the polyamine pathway was obtained by using a wide range of metabolic …
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EFFECT OF NICOTINE ON LUNG S-ADENOSYLMETHIONINE AND PNEUMOCYSTIS PNEUMONIA DEVELOPMENT
… and necessary for the synthesis of the essential polyamines spermidine and spermine. In the target tissue of "Pneumocystis", the lung, levels of AdoMet were previously shown to be depleted experimentally using nicotine. Here we show that chronic administration of nicotine in an animal model of PcP …
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Dual Delivery Systems Based On Polyamine Analog Benspm As Prodrug And Gene Delivery Vectors
… vectors. BENSpm (N1, N11-bisethylnorspermine), a polyamine analogue targeting the intracellular polyamine pathway, draws our special attention because of the following reasons: (1) polyamine pathway is frequently dysregulated in cancer; (2) BENSpm exhibits multiple functions to interfere with the …