Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Polyamine Metabolism"”.
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Transgenic manipulation of polyamine metabolism in poplar
<p>Polyamines are low molecular weight polycations found in all living organisms. They are involved in plant stress response and development. The study was aimed at analyzing the effects of altered polyamine metabolism on the polyamine and related pathways in transformed poplar cells overexpressing …
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Polyamine metabolism in Arabidopsis: Transgenic manipulation and gene expression
<p>The metabolism of polyamines (Putrescine, Spermidine and Spermine) in wild type and transgenic Arabidopsis thaliana (Col 0 ecotype) plants was studied using the techniques of transgenic manipulation and gene expression. Two specific objectives were: (1) To study the effects of inducible and …
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Understanding polyamine metabolism through transgenic manipulation in poplar suspension cultures
<p>Polyamines are low molecular weight aliphatic amines that are obligatory requirements for cell survival and growth. The commonly occurring polyamines in plants are putrescine, spermidine, and spermine. Suspension cultures of poplar (Populus nigra x maximowiczii), transformed with a mouse …
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Effect of Water-deficit Stress on Cotton During Reproductive Development
… effects of water stress on leaf physiology and metabolism have been extensively documented. However, information is lacking on the effect of water-deficit stress on the cotton flower. It was hypothesized that water-deficit stress would impair gas exchange functions which consequently would …
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ANALYSIS OF VARIATIONS IN SUSCEPTIBILITY AND TRANSCRIPTOME RESPONSES IN TOMATO TO TWO-SPOTTED SPIDER MITE FEEDING
… of MicroTom resistance may involve changes in polyamine metabolism, and up regulation of cystiene protease inhibitors.
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The Role of Polyamines in Osmotic Stress Tolerance in Gulf Killifish Fundulus Grandis
Polyamines are a diverse class of aliphatic molecules that are highly polycationic at physiological intracellular pH. Polyamine levels are regulated by the coordinated actions of arginase (Arg), ornithine decarboxylase (Odc), and polyamine oxidase (Pao). Although little is known of their functions …
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Characterization of the expression profile of polyamine biosynthetic genes (Spermidine synthase) and polyamine metabolic regulation in arabidopsis
<p>Polyamines are ubiquitously distributed cationic compounds, which play important roles in numerous cellular functions in plants. This study was aimed at elaborating the regulation of polyamine biosynthetic gene expression and polyamine metabolism. The organ/tissue specific expression patterns of …
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Transcriptomic Signatures of Skeletal Muscle Adaptation: Disuse, Rehabilitation, and Resistance Exercise Intervention
… with translation, rRNA processing, and polyamine metabolism are positively correlated with strength. In summary, our study unveils novel insights into the molecular mechanisms driving skeletal muscle responses to disuse and resistance exercise training. By integrating transcriptomic …
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Dual Delivery Systems Based On Polyamine Analog Benspm As Prodrug And Gene Delivery Vectors
… vectors. BENSpm (N1, N11-bisethylnorspermine), a polyamine analogue targeting the intracellular polyamine pathway, draws our special attention because of the following reasons: (1) polyamine pathway is frequently dysregulated in cancer; (2) BENSpm exhibits multiple functions to interfere with the …
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Gene expression profiling of polyamine-depleted Plasmodium falciparum
Polyamines play an important role in DNA, RNA and protein synthesis as well as a variety of other biological processes (cell division, differentiation and death) as outlined in Chapter 1. Assaraf and co-workers (1984) demonstrated that treatment with DFMO resulted in the inhibition of polyamine …
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… identified dysregulation of one-carbon metabolism in NASH. This dissertation details the molecular mechanisms for how these proteomic changes can drive NASH pathogenesis and be targeted for therapeutic purposes. Chapter 1 provides an extensive background on NASH prevalence and …
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Omics Techniques Applied to Diabetes Research - Focus on HSL-Null Mice and Clonal β-Cells
… changes in expression of proteins involved in polyamine metabolism were observed in the liver of HSL-null mice, which could be responsible for the increased liver weight characterizing HSL-null mice. The physiological response of HSL-null mice to aerobic treadmill exercise was also investigated …
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EFFECT OF NICOTINE ON LUNG S-ADENOSYLMETHIONINE AND PNEUMOCYSTIS PNEUMONIA DEVELOPMENT
… and necessary for the synthesis of the essential polyamines spermidine and spermine. In the target tissue of "Pneumocystis", the lung, levels of AdoMet were previously shown to be depleted experimentally using nicotine. Here we show that chronic administration of nicotine in an animal model of PcP …