Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Polyalanine"”.
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Experimental characterization of polyalanine helices in short and long contexts
… a single folded conformation, simple helical polyalanine peptides exists as a manifold of partially helical conformers. The Ac-Hel template characterizes short helical conformations that exist within larger manifolds. Using an isolation and solubilization methodology, t/c measurements of …
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Copper-catalyzed arylation of 1,2-amino alcohols. Synthesis of N-terminal, peptide helix initiators, and characterization of highly helical, capped polyalanine peptides
… used. II. Recent advances in solubilization of polyalanine and helix stabilization by end capping were combined to synthesize a series of highly helical, water-soluble polyalanine peptides permitting straightforward context-free investigation of this most common helix- forming [alpha]-amino …
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Synthesis and mass spectrometry studies of oligopeptides
… of model N- and C-terminal cysteine polyalanine peptides in which one L-alanine was substituted by a D-alanine viz. CAA<sup>D</sup>A and AA<sup>D</sup>AC, were measured by the extended Cooks kinetic method. Gas-phase acidities of CAA<sup>D</sup>A and AA<sup>D</sup>AC were measured to …
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Thermochemical differences in lysine and lysine-homolog containing oligopeptides: Determination of basicity and gas-phase structure through mass spectrometry, infrared spectroscopy, and computational chemistry
… The peptides characterized were acetylated polyalanine di-, tri-, and tetra- peptides containing a proton-accepting probe: lysine and or the non-proteinogenic lysine-homologs: ornithine, 2,4-diaminobutyric acid, and 2,3-diaminopropionic acid. Peptides were studied in isomeric pairs for which …
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Exploring Pain Neurobiology: Molecular Investigation of Genetic Sensory Disorders
… cause global, lifelong painlessness, homozygous polyalanine expansions within a discrete range lead to facially-localised, enhanced itch in childhood (Midface Toddler Excoriation Syndrome – MiTES). Observations of the CIP- and MiTES-associated polyalanine expansion mutants in a non-neuronal cell …
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Characterization of the large diameter fibers in egg case silk : identification of a core fibroin, TuSp1, and localization of fibroin-like molecules, ECPs, from the black widow spider, latrodectus hesperus
… of TuSp 1 revealed the lack of long stretches of polyalanine and glycine-alanine sub-repeats, which are commonly found in minor ampullate and major ampullate silks. Polyserine blocks and short polyalanine stretches were highly represented in the TuSp 1 amino acid sequence. Our data support the …
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Determination of the proton affinities of gas phase peptides by mass spectrometry and computational chemistry
… proton affinities calculated for helical polyalanine and Aib (aaminoisobutytic acid) modified polyalanine peptides with C-terminal basic residues (Ac A<sub>n</sub>K and Ac-(AibA)<sub>n</sub>-Dap) are much larger than proton affinities calculated for the corresponding peptides with …
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Investigation into the Molecular Biology of Human Genetic Sensory Disorders of Painlessness and Itch
… known to be associated with CIP, including the polyalanine tract expansion mutation to 19 alanine repeats. Interestingly, expansion mutation of the same gene to 18 alanines result in a completely different phenotype, an intense itch condition referred to as midface toddler excoriation syndrome …
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Energetics of [alpha]-helix formation in peptides and proteins
… rigorous characterization of spaced, solubilized polyalanine peptides as the ideal host to study intrinsic helical propensities in a solvent-exposed, context-free model.
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The variation of the gas phase acidity of a cysteine residue in oligopeptides
… peptides were close to those of the cysteine-polyalanine analogues.</p><p>Computational studies were performed through conformer search, geometry optimization, and energy calculations using the Spartan and the Gaussian suite of programs. The results showed that the low energy conformations of …