Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 89 for “"Polyadenylation"”.
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Prediction of mRNA polyadenylation sites in the human genome and Mathematical modeling of alternative polyadenylation
Messenger RNA (mRNA) polyadenylation plays many important roles in the cell, such as transcription termination, mRNA stability and transportation, and mRNA translation in eukaryotic cells. A large number of human and mouse genes have multiple polyadenylation sites (referred to as poly(A) sites) …
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Cdk12 regulates DNA repair Genes by suppressing intronic polyadenylation
… transcription elongation, splicing, and cleavage/polyadenylation. Unlike other transcriptional CDKs that regulate most expressed genes, Cdk12 depletion abrogates the expression of homologous recombination (HR) genes relatively specifically, suppressing the HR DNA damage repair pathway and …
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The Role of Cleavage and Polyadenylation Spcific Factor 6 (CPSF6) in Hematopoiesis
<p>Cleavage and polyadenylation specific factor 6 (<em>Cpsf6</em>) translocation is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage …
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A bioinformatics framework for RNA structure mining, motif discovery and polyadenylation analysis
… Further, the role played by structure in mRNA polyadenylation was investigated. Polyadenylation is an important step towards the maturation of almost all cellular mRNAs in eukaryotes. Studies have identified several cis-elements besides the widely known polyadenylation signal (PAS) element …
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Polyaseeker: a computational framework for identifying polyadenylation cleavage site from RNA-seq
Alternative polyadenylation (APA) of mRNA plays a crucial role for post-transcriptional gene regulation. Recently, advances in next generation sequencing technology have made it possible to efficiently characterize the transcriptome and identify the 3'end of polyadenylated RNAs. However, no …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
… 25, CFIm25) is a key regulator of alternative polyadenylation (APA). NUDT21 depletion causes 3’UTR shortening via APA leading to enhanced mRNA stability and protein translation. This NUDT21 reduction promotes tumor growth in glioblastoma by enhancing expression of oncogenes. Cancer and IPF …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
… this disease. It has been shown that alternative polyadenylation (APA) due to depletion of Nudix Hydrolase 21(NUDT21) is involved in several disease states including the chronic lung disease idiopathic pulmonary fibrosis (IPF). Additionally, hyaluronan, an extracellular matrix glycosaminoglycan …
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The Role of Alternative Splicing and Alternative Polyadenylation in Regulating Activated T cell Biology
Alternative splicing and alternative polyadenylation are now recognized to occur in the vast majority of human genes. Both have the potential to alter the identity of the encoded protein, as well as control protein abundance, protein localization, or association with other factors. T cells provide …
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Polyadenylation of ribosomal RNA in response to picornavirus infection in honey bees (Apis mellifera)
At least eighteen different picornaviruses can infect honey bees (Apis mellifera). The combination of the virulence of these pathogens as well as their transmissibility through Varroa destructor, an ectoparasitic mite, can cause severe declines in honey bee populations. Polyadenylated (polyA) rRNA …
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Twist of messenger Fate: novel mechanisms for TDP43 in modulating mRNA decay and alternative polyadenylation
… role in the 3’UTR, modulating mRNA alternative polyadenylation and promoting the generation of shorter transcripts. This finding is supported by the direct interaction of TDP43 with the cleavage stimulation factor, a core component of the polyadenylation machinery. These results broaden our …
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Unravelling TERRA regulation by the interplay of two mechanisms: RALY interaction and telomere-specific polyadenylation
… with the hnRNP RALY and telomere-specific polyadenylation. RALY is an RNA binding protein that preferentially binds to RNAs containing poly(U) stretches and it plays key roles in RNA maturation and stabilization processes. An interactome study identified RALY as a TERRA interacting factor …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… used to control gene expression is alternative polyadenylation (APA). Approximately 70% of eukaryotic transcripts have multiple possible polyadenylation sites (PAS), allowing expression of mRNA isoforms with different 3’ untranslated regions (3’ UTR) as well as different open reading frames. …
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Architecture of eukaryotic mRNA 3' end processing machinery and insights into the mechanism of polyadenylation
… by a multi-protein complex known as cleavage and polyadenylation factor (CPF). CPF, along with accessory cleavage factors (CF) IA and IB, cleaves the pre-mRNA within the 3' untranslated region (UTR) and adds a poly(A) tail. Previous work has shown that CPF is a fourteen-subunit complex that is …
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Promoter directionality is controlled by U1 snRNP and polyadenylation signals in mouse embryonic stem cells
RNA polymerase II (RNAPII) transcription is a tightly regulated process controlling cell type and state. Advancements in our understanding of how transcription is regulated will provide insight into the mechanisms controlling cell identity, cellular differentiation, and its misregulation in …
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Bioinformatics study of mammalian MRNA polydenylation
Messenger RNA polyadenylation is one of the key post-transcriptional events in mammalian cells, which have influences on many aspects of mRNA metabolism. Several human diseases have been shown to associate with abnormal polyadenylation, highlighting the importance of this process. The availability …
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Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
<p>Alternative polyadenylation has been implicated in the regulation of mRNA translation and stability, as well as mRNA and protein localization. However, it is unclear to what extent alternative polyadenylation regulates these processes uniquely in specific cell types. Using a newly developed …
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Posttranscriptional regulation with regard to cleavage factor I (CFI) associated alternative polyadenylation and methyltransferase A (MTA) assisted m6A modifications in Arabidopsis thaliana
… affecting the fate of a transcript. Alternative polyadenylation (APA) is associated with many regulatory aspects. It describes the addition of the poly(A) tail at alternative sites inside the transcript. This is achieved by the cleavage and polyadenylation machinery. Cleavage factor I (CFI) is a …
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Functional specialization of Arabidopsis poly(A) polymerases in relation to flowering time and stress
Polyadenylation is a decisive 3’ end processing step during the maturation of pre-mRNAs. The length of the poly(A) tail has an impact on mRNA stability, localization and translatability. Accordingly, many eukaryotic organisms encode several copies of canonical poly(A) polymerases (cPAPs). The …
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Role of RNA Processing Factors in the Expression of Flt-1 and its Secreted Variant, sFlt-1
… mRNA for transmembrane Flt-1, whereas cleavage/polyadenylation within this intron, preserving the exon 13/intron 13 junction, yields sFlt-1 mRNA. Despite the likely importance of sFlt-1 in VEGF signaling, little is known about the regulation of its expression. Previous studies using an Flt-1 …
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