Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"PolyQ huntingtin"”.
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A study on non-canonical autophagy signalling
… such as the neurodegeneration-associated mutant polyQ-huntingtin. This study has identified how ULK1 upregulates autophagy upon glucose starvation and induces the formation of PI(5)P-containing autophagosomes by activating PIKfyve, revealing a novel mechanism by which autophagy is induced.
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Protein misfolding toxicity and inclusion formation in cellular models of neurodegeneration
… lateral sclerosis (ALS) and polyglutamine (polyQ) expanded huntingtin, which causes Huntington’s disease (HD). Genetic, biochemical, and pathological findings implicate RGNEF and Matrin3 in Amyotrophic Lateral Sclerosis (ALS). In this thesis we establish two novel humanized yeast models to …