Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Poly-ADP-Ribose Polymerases"”.
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Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice
Adenosine diphosphate (ADP) ribosylation is a post-translational modification dependent on the transfer of ADPr units from nicotinamide adenine dinucleotide (NAD+) on to a plethora of biomolecules (i.e., proteins, DNA, RNA, etc.) in response to physiological stressors (i.e., nutrient deprivation, …
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Characterization of Novel Substrates of the Tankyrase and RNF146 Destruction Complex and Mechanisms of its Regulation
Poly-ADP-ribose is a post-translational modification that was first described over 50 years ago as a polymer derived from nicotinamide adenine dinucleotide or NAD. Since then, a family of 17 enzymes responsible for generating Poly-ADP-ribosylation or PARylation post translational modification has …
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Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… for many NAD+-dependent enzymes, such as poly(ADP-ribose) polymerases (PARPs; e.g., PARP-1) or sirtuins (SIRTs; e.g., SIRT-1), which many of them are known to play an important role in gene regulation. In mammalian cells, NAD+ is synthesized from nicotinamide mononucleotide (NMN) and ATP, …
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Chemical Genetic and Genomic Discovery of PARP-1-Dependent Mechansims of Transcriptional Regulation
Poly(ADP-ribose) polymerases, or PARPs, are a family of enzymes that modulate diverse biological processes through covalent transfer of ADP-ribose from NAD+ onto target proteins. These targets of post-translational modification as well as the genomic targets, or binding sites, to which the nuclear …
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Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target
Poly(ADP-ribosyl)ation is a reversible post-translational modification of histones and nuclear proteins rapidly stimulated by DNA damage. Its homeostasis is a dynamic process regulated by the synthesizing enzymes poly(ADP-ribose) polymerases (PARPs) and the degrading enzyme poly(ADP-ribose) …
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Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins
… (APC/C-Cdc20). TNKS belong to the poly-ADP-ribose polymerases (PARP) family of enzymes that PARylate their substrates, leading to ubiquitination and subsequent degradation. TNKS bind their protein substrates through an ankyrin-repeat domain comprising five so-called Ankyrin Repeat …
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The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response
… three classes of NAD+ dependent enzymes: cyclic ADP-ribose synthases, sirtuins, and poly (ADP)-ribose polymerases (PARPs). The cyclic (ADP)-ribose synthase, CD38, is the primary NAD’ase in cells and has historically been regarded as an important cell surface molecule in cells of hematopoietic …
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Molecular Effects of the Nampt Inhibitor FK866 on Leukemia Cells
… a substrate for NAD+-degrading enzymes such as poly (ADP-ribose) polymerases (PARPs), CD38, and sirtuins, regulating processes that undergo fundamental changes during malignant transformation. Although NAD+ can be generated de novo from tryptophan precursor, the major route of biosynthesis is …
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Integrative multiomic insights into Alzheimer’s disease pathology
… and DNA repair through NAD<sup>+</sup>-consuming poly (ADP-ribose) polymerases (PARPs). I found that increasing the bioavailability of NAD<sup>+</sup> pharmacologically or by suppressing PARP is neuroprotective in fly models. Using UK Biobank data, I showed that polymorphisms in the human *PARP1* …
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Interactions between Folate Deficiency and β-Nicotinamide Adenine Dinucleotide Deficiency and Conformational Study of Thymidylate Synthase and its Physiological Relevance
… NAD+, the substrate of two families of enzymes, poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs). PARP-1 is thought to mediate the repair of BER intermediates and to suppress homologous recombination (HR); SIRT1 is a histone deacetylase. Thus, the balance between folic acid and NAm may …
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Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods
Several obstetrical complications, including maternal obesity (MO) and preeclampsia (PE), are associated with states of chronic gestational inflammation and poor pregnancy outcomes. However, commonalities and/or differences from these divergent chronic inflammatory insults on placental development …