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Showing 1 to 20 of 33 for “"Poly ADP ribose polymerase (PARP)"”.

  1. Untersuchungen zur Inhibierung der Expression der Poly(ADP-ribose)Polymerase (PARP) nach Infektion mit Toxoplasma gondii

    Gais, Andrea Nadja2012

    … Apoptose auch die Inhibierung der Expression der Poly(ADP-Ribose) Polymerase (PARP)-1. PARP-1 ist ein nukleäres Protein und spielt eine wichtige Rolle in verschiedenen zellulären Abläufen einschließlich DNA Reparatur, Apoptose, Nekrose und Regulation der Genexpression. Außerdem ist es an der …

    goettingen Repository record

  2. Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis

    Andres, Robert DouglasUniversity of Illinois at Urbana-Champaign2015

    … inhibits cleavage of the DNA repair enzyme poly-(ADP-ribose) polymerase (PARP) following treatment with NMDA. Inhibition of ERK with MEK inhibitors (PD98059 and U0126) significantly decreased PARP cleavage (cPARP), while inhibition of PP2A with 10 nM okadaic acid, significantly increased …

    uiuc Repository record

  3. Mechanismen der Toxoplasma-gondii-vermittelten Inhibierung der Apoptose in humanen Wirtszelllinien

    Goebel, StefanUniversität Würzburg

    … werden. Zweitens wird die Expression der Poly-(ADP-Ribose)Polymerase (PARP) durch T. gondii inhibiert. Beide Mechanismen könnten an der Inhibierung der Wirtszellapoptose durch T. gondii beteiligt sein und dem Parasiten damit sein intrazelluläres Überleben sichern.

    wurz-thes Repository record

  4. Structure and function of the human Poly(ADP-ribose) polymerase enzyme family

    Rood, Jennifer E. (Jennifer Evelyn)Massachusetts Institute of Technology2013

    The poly(ADP-ribose) polymerase (PARP) family of enzymes in humans is comprised of 17 proteins. PARP-1, the first member of the family, synthesizes a large, complex post-translational modification, poly(ADP-ribose). While PARP-1 and some other PARPs have been extensively functionally characterized, …

    mit Repository record

  5. Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage

    Hawrylyshyn, Krista MThe University of Western Ontario2015

    … critical to vascular health. NAD+, which drives poly (ADP-ribose) polymerase (PARP) and sirtuin (SIRT) reactions, can be compromised and strategies for overcoming this limitation in the vasculature do not exist. This study determines if nicotinamide riboside (NR) delivery can augment NAD+ stores …

    uwo Repository record

  6. Role of C-Met and Egfr In Acquired Resistance to Parp Inhibitors In Triple-Negative Breast Cancer

    Yam, Clinton, <p><a href="https://orcid.org/0000-0002-0809-0851?lang=en" target="_blank">https://orcid.org/0000-0002-0809-0851</a></p>2020

    … prognosis and treatment options are limited. The Poly (ADP-ribose) polymerase (PARP) inhibitors, olaparib and talazoparib, were recently approved for metastatic breast cancer (including triple-negative breast cancer) in patients with a germline <em>BRCA1/2</em> mutation. Despite impressive …

    uthsc Repository record

  7. MODELING COHESIN-DEPENDENT ONCOGENESIS IN VITRO AND IN VIVO: POSSIBLE AMELIORATIVE EFFECTS OF PARP INHIBITION

    TOTARO, SIMONAUniversità degli Studi di Milano2025

    … masses in the brain. I also showed that Poly (ADP-ribose) polymerase (PARP) depletion or inhibition which is used to treat forms of cancer with defects in DNA repair ameliorated phenotypes of SA-deficient animals. Finally, I studied the effect of STAG2 downregulation in human in vitro …

    milano Repository record

  8. Evaluation of selective γ-secretase inhibitors as novel modulators of TNF-α-mediated apoptosis

    O'Brien, CiaraUniversity College Cork2021

    … Utilizing the cleavage of caspase 3 and Poly ADP ribose polymerase (PARP) in target cells as a readout, we tested the anti-apoptotic characteristics of a panel of well characterized γ-secretase inhibitors. In this study, we show that loss of presenilin expression is associated with …

    cork Repository record

  9. Enzymatic synthesis of defined-length poly(ADP-ribose) and the investigation of cell-permeable poly(ADP-ribose) glycohydrolase inhibitors

    Yang, WoojinUniversity of Illinois at Urbana-Champaign2016

    Poly(ADP-ribosylation) (PARylation) is an important post-translational modification that maintains genomic stability in a cell. Engaging in important cellular processes such as DNA repair and cell death signaling, PARylation has gathered considerable interest as a target for genotoxic chemotherapy …

    uiuc Repository record

  10. SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1

    Lisa Gutgesell (22483153)2025

    … this is typically only used to determine if Poly (ADP-Ribose) Polymerase (PARP) inhibitors are an appropriate treatment option. One potential biomarker my lab has identified is SOX2. The expression of SOX2 was linked to an increased Gleason score at diagnosis and decreased time to metastasis …

    uic

  11. Parp Inhibitor Upregulates Pd-L1 Expression and Enhances Cancer-Associated Immunosuppression

    Jiao, Shiping, <p>0000-0001-6546-9369</p>2017

    … to cytotoxic anticancer agents. Inhibitors of poly (ADP-ribose) polymerase (PARP) have shown substantial cytotoxic effects against tumors with defects in DNA damage responses. However, whether a crosstalk between PARP inhibition and immune checkpoints exists remains unclear. Here, it has been …

    uthsc Repository record

  12. Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds That Induce G1 Cell Cycle Arrest

    Dothager, Robin ShaneUniversity of Illinois at Urbana-Champaign2015

    … to analysis of potential inhibitors of the poly (ADP-ribose) polymerase (PARP) family of enzymes. The major focus has been the identification of triphenylmethylamides (TPMAs), which induce apoptosis in melanoma cells after causing growth arrest in the G1 phase of the cell cycle. Compounds …

    uiuc Repository record

  13. Cellular functions and enzymatic activity of the poly(ADP-ribose) polymerase protein family

    Vyas, Sejal (Sejal Kamlesh)Massachusetts Institute of Technology2014

    The poly(ADP-ribose) polymerase (PARP) protein family consists of seventeen enzymes and generates ADP-ribose (ADPr) posttranslational modifications onto target proteins using NAD* as a substrate. While functions for PARPs in the nucleus, such as in DNA damage repair and transcriptional regulation, …

    mit Repository record

  14. Investigating the role of protein ubiquitylation in the maintenance of genome stability

    Feeney, LauraUniversity of Dundee2017

    … cells, namely synthetic lethality with the poly-ADP ribose polymerase (PARP) inhibitor olaparib, as a means of screening for new HR factors. In this manner, I identify the E2 ubiquitin conjugating enzyme UBE2S as a novel factor required for olaparib resistance, and confirm its direct …

    dundee Repository record

  15. Gingko biloba extracts protect auditory hair cells from cisplatin-induced ototoxicity by inhibiting perturbation of gap junctional intercellular communication

    최, 성준2014

    … in immunostaining and decreased caspase 3 and poly-ADP- ribose polymerase (PARP) bands, which were increased in cisplatin-treated cells in Western blots. EGb prevented abnormal intracellular locations of Cx 26, 30, 31, and 43 in cells treated with cisplatin and increased quantities of Cx bands. …

    ajou Repository record

  16. PARP inhibition in combination with radiation therapy for the treatment of feline oral squamous cell carcinoma

    Hampel, Jordan MarieUniversity of Illinois Urbana-Champaign2025

    … strategies to enhance RT efficacy are needed. Poly (ADP-ribose) polymerase (PARP) is a key molecule involved in single stranded DNA break repair. PARP inhibitors (PARPi) are predicted to amplify RT-induced lethal DNA damage, and combinatorial strategies with PARPi and RT are being investigated …

    uiuc Repository record

  17. Comparison of dose-dependent outcomes in induction of cytogenotoxic responses by novel glucosyl flavonoids

    Engen, Anya, author, Kato, Takamitsu, advisor, Hanneman, William, advisor, Legare, Marie, committee member, Bouma, Gerrit, committee memberColorado State University. Libraries2014

    … the effects of flavonoids on DNA repair via the poly(ADP ribose) polymerase (PARP) pathway using ELISA showed that all three natural flavonoids along with MI and MO were capable of inhibiting PARP activity by 50%. Quercetin was observed to be the strongest natural inhibitor of PARP. In growth …

    colostate Repository record

  18. Untersuchungen zur CD40 induzierten Expression von A1 in B-Lymphozyten der Maus

    Kuß, AndreasUniversität Würzburg

    … zeigten, dass es den Abbau des Caspasesubstrates Poly-ADP-Ribose-Polymerase (PARP), die Aktivierung der Caspase 7, aber auch die Freisetzung radikalischer Sauerstoffverbindungen aus den Mitochondrien unterdrückte. Das CD40-Signal scheint sich also oberhalb von A1 in zwei Hauptkomponenten …

    wurz-thes Repository record

  19. Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia

    Smith, PaulUniversity of East Anglia2011

    … ligase. Cell cycle analysis in combination with poly ADP ribose polymerase (PARP) cleavage assays show TGFβ causes cell quiescence, and that the inhibition of the signalling pathway releases cells from growth arrest and enhances Imatinib-induced cell death. Collectively, data highlights a …

    east-anglia Repository record

  20. Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury

    Aimalohi EsechieThe University of Texas Medical Branch2008

    … cell death through hyper-activation of poly (ADP-ribose) polymerase (PARP-1). The purpose of this study was to investigate and counteract pulmonary dysfunction associated with nitrosative stress generated after B + S inhalation injury in an ovine and murine model of ALI. \r\nIn our time …

    utmb Repository record

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