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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Poly (ε-caprolactone)"”.
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The Encapsulation and Release of Flutamide Using Poly (ε-Caprolactone) Microspheres
… release delivery systems using non-toxic polymeric microspheres. These polymeric microspheres encapsulate the active agent improving its bioavailability and compliance, reducing drug toxicity and side effects. The aim of this investigation was to develop a controlled release FLT delivery …
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Nanoscale Confinement Effects on Poly(ε-Caprolactone) Crystallization at the Air/Water Interface & Surfactant Interactions with Phospholipid Bilayers
… (2D) nanoscale confinement effects on poly(ε-caprolactone) (PCL) crystallization were probed through crystallization studies of PCL-b-poly(tert-butyl acrylate) (PCL-b-PtBA) copolymers, PCL with bulky tri-tert-butyl ester endgroups (PCL triesters), PCL with triacid end groups (PCL …
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Crystallization and Melting Studies of Poly(ε-caprolactone) and Poly(ethylene oxide) using Flash™ Differential Scanning Calorimetry and Preparation and Characterization of Poly(δ-valerolactone) Fractions
… crystallization and melting temperatures of poly(ε-caprolactone) were correlated using fast differential scanning calorimetry. The melting kinetics was found to be independent of isothermal crystallization temperature and time. The conventional Hoffman-Weeks method could not be used to …
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Self-Consistency of the Lauritzen-Hoffman and Strobl Models of Polymer Crystallization Evaluated for Poly(ε-caprolactone) Fractions and Effect of Composition on the Phenomenon of Concurrent Crystallization in Polyethylene Blends
Narrow molecular weight fractions of Poly(ε-caprolactone) were successfully obtained using the successive precipitation fractionation technique with toluene/n-heptane as a solvent/nonsolvent pair. Calorimetric studies of the melting behavior of fractions that were crystallized either isothermally …
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Temperature and Water Responsive Shape Memory Polymers for Soft Tissue Expansion
A biodegradable thermoplastic shape memory polymer which can be used for 3D printing patient specific soft tissue expanders was synthesized and characterized. The bottlebrush polymer with Poly (vinyl alcohol) backbone and polyurethane side chains exhibited shape memory effect. Using an …
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Crystallization and melting behavior of (ε-caprolactone)-based homopolymer and triblock copolymer
… theory to the crystallization kinetics of poly(ε-caprolactone), PCL. This theory has successfully predicted a number of experimental observations such as the temperature dependence of spherulitic growth rates and the inverse relation between undercooling and the lamellar thickness. Claims …
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Investigation of adipose-derived mesenchymal stem cells interaction with electrospun demineralized bone matrix nanofiber scaffolds
… short-term in culture media was investigated. Poly (ε-caprolactone) (PCL) scaffolds were used as control surfaces. Live cell stain calcein-AM and CellTiter 96® Non-Radioactive Cell Proliferation assays were used for cell adhesion and cell proliferation, respectively. DBM scaffolds supported …
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Characterisation of the in vitro effects of Asiatic acid in Glioblastoma
… Thus we formulated asiatic acid-loaded poly-ε-caprolactone nanoparticles for sustained and localised delivery in glioblastoma cells in vitro. Asiatic acid nanoparticles were prepared using solvent displacement method and showed an average diameter of 150nm, average negative surface …
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Formation of Cyclodextrin-Drug Inclusion Compounds and Polymeric Drug Delivery Systems using Supercritical Carbon Dioxide
… the complex formation and in the foaming of the polymer scaffold. The co-solvents, ethanol, ethyl acetate and acetone, were explored in each stage, as needed, to improve the solvent power of CO2. The first goal was to promote cyclodextrin-drug complex formation. Complex formation by traditional …
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Miscibility, Viscosity, Density, and Formation of Polymers in High-Pressure Dense Fluids
… volumetric properties, and viscosity of poly (methyl methacrylate) (PMMA), poly (ε-caprolactone) (PCL) and their blends. Homopolymerization and copolymerizations of methyl methacrylate (MMA) and 2-methylene-1,3-dioxepane (MDO) in mixtures of acetone + CO2 have also been explored. The …
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SMART POLYMERIC DRUG NANOCARRIERS FOR BIOMEDICAL APPLICATIONS
Biodegradable polymeric nanoparticles (nps) have shown to be promising forms for the delivery of a wide array of drug formulations, because of their ability to: (i) increase the drug half-life in the blood stream, (ii) enhance the solubility of poorly-water soluble drugs, which represents the main …
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DRUG ELUTING TISSUE ENGINEERED VASCULAR GRAFTS
… constructs comprised of a macrofiber diameter poly(ε-caprolactone) (PCL) type I collagen outer layer that promotes vascular smooth muscle integration and media layer formation, a nanofiber diameter PCL type I collagen middle layer that promotes endothelial monolayer formation, and a microfiber …
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A Multicomponent Bioactive Tissue-Engineered Blood Vessel: Fabrication, Mechanical Evaluation and Biological Evaluation with Physiological-Relevant Conditions
… graft materials, we demonstrated a degradable polyester-fibroin composite tubular scaffolds which shows well-integrated nanofibrous structure, endothelial-conducive surface and anisotropic mechanical property, suitable as engineered vascular constructs. Tissue regeneration needs not only …
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Characterization of a Nanoparticle Drug Delivery System for the Treatment of Inflammation in Spinal Cord Injury
… drug delivery nanocarrier (minocycline loaded in poly-ε-caprolactone NPs, PCL Mino) <i>in vitro</i> and <i>in vivo</i>. Specifically, we demonstrated a reduced activation of microglia/macrophage after PCL Mino treatment <i>in vitro</i> and a reduction of cells with phagocytic-like phenotype, up to …
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Designing High Performing Durable Bio-Based Coatings for Packaging Applications
… packaging applications using renewable biopolymers. These include cellulose, extracted from plants, and chitin, sourced from mushrooms and food waste like crustacean exoskeletons. These natural polymers can form strong, high-performance films but are limited by moisture sensitivity and …
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Design and Optimization of Angiogenic, Antibacterial Si-Zn-Hydroxyapatite for Use as Filler Particles in Polycaprolactone Nanocomposites
… Si-Zn-HAp nanoparticles were incorporated into a poly(ε-caprolactone) (PCL) matrix. A novel fabrication strategy, combining short-chain poly(ethylene glycol) (PEG) end-functionalization of PCL with an antisolvent precipitation method, was developed to overcome typical challenges of filler …
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Effect of Mechanical Environment on the Differentiation of Bone Marrow Stromal Cells for Functional Bone Tissue Engineering
… mechanical properties using a synthetic polymer system with tunable properties like polyurethanes. Finally, BMSCs seeded within the biomaterial scaffold can be cultured in a perfusion flow bioreactor to stimulate osteoblastic differentiation and the deposition of bioactive factors. Using …
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Amphiphilic Diblock Copolymers: Study of Interpolyelectrolyte Complexation in Organic Media and Nanoencapsulation of Melatonin
Two oppositely charged homopolyelectrolytes poly(2-(methacryloyloxy)ethyl¬dimethyl-ethyl¬ammonium bromide) (PDMAEMAQ) and poly(acrylic acid) (PAA), and amphiphilic diblock copolymers based on polystyrene and the ionizable block poly(acrylic acid) were synthesized via Atom Transfer Radical …
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Synthesis and Characterization of Protein-Polymer Core-Shell Structures
… of their self-assembly behavior with various polymers is of increasing interest for development of functional materials. Compared to inorganic or organic nanoparticles, BNPs are truly monodisperse and can be modified in a well defined manner. Both of these attributes are critical for the …
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Investigation of cell-based therapies employing microcapsules and microspheres: encapsulation and controlled release
… Uniform core/shell MCs co-encapsulating poly (ε-caprolactone) MSs with NIH 3T3 fibroblasts as model anchorage dependent cells (ADCs) were designed to increase the survival of the cells via re-establishment of cell-substrate interactions. The core/shell MCs with the altered intracapsular …
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