Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Poly(lactide-co-glycolide) (PLGA)"”.
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Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis
… delivery, providing targeting, protection, and controlled-release capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) (PLGA) are biodegradable, exhibit tunable drug release, and have encapsulated a wide variety of biological agents. However, PLGA …
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Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application
… of this study is to determine the potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable …
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Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
… of rifampicin (RIF)-loaded microparticles were compared for their stability during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) as well as …
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Development of a Novel Vaccine Adjuvant System Utilizing an In Situ Implant System to Modified Release
… release and altered immune response, which could act as a booster administration. This type of system was selected because ISI systems are used for long acting administration of various drugs and ease of administration. A typical ISI system is comprised of hydrophilic organic solvent (e.g. …
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Controlled release in inhalation
Increasingly complicated medication regimens associated with the necessity of the repeated dosing of multiple agents used in treating pulmonary disease has been shown to compromise both disease management and patient convenience. In this study the viability of spray drying to introduce controlled …
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Development of supercritical processes for particle coating / encapsulation with polymers
This work presents the investigation of particle coating using supercritical fluid processes as novel coating approaches to coat particles from 20 nanometers to 500 microns with different polymers. Particle coating using different supercritical technologies of a modified rapid expansion of a …
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Synthesis and Characterization of Injectable Star-shaped Poly(Lactide-co-Glycolide-co-Acrylate) Macromers
<p>Polymers, as hydrogel macromers, have been studied and widely applied to develop scaffolds in tissue engineering since 1990s, because they offer a number of advantages over other materials such as the ability to tailor mechanical properties and degradation kinetics based on various applications. …
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A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery
<p>Poly lactide‑co‑glycolide (PLGA) polymer has been the polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic …
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Nanomicelles And Liposomes For Improving Drug Delivery of Small Molecules And siRNA Therapeutic Agents
… choroidal endothelial (RF/6A) cells and human corneal epithelium (CCL 20.2) cells. Cellular uptake and in vitro distribution studies using flow cytometry and confocal microscopy respectively indicated an elevated uptake of TAC-NMF in a time-dependent manner. Biocompatibility assay using …
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Multiphase, Multicomponent Systems: Divalent Ionic Surfactant Phases and Single-Particle Engineering of Protein and Polymer Glasses
… divalent ionic surfactant salts, and protein and polymer glasses. There has been extensive interest in understanding the phase behavior of divalent ionic surfactants due to the many applications of ionic surfactants in which they come into contact with divalent ions, such as detergency, oil …
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Investigation of properties affecting controlled release of macromolecules from PLGA microspheres
Poly(lactide-co-glycolide), or PLGA, microspheres offer a widely-studied biodegradable option for controlled release of therapeutics. An array of fabrication methodologies have been developed to produce these microspheres with the capacity to encapsulate therapeutics of various types; and produce …
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DEVELOPMENT OF NEW PEPTIDE-BASED NANOMATERIALS AS POTENTIAL TOOLS FOR CRYOPRESERVATION OF TISSUES AND ORGANS
… nature, as several organisms living in extreme conditions produce specific proteins, termed antifreeze (glyco)proteins (AF(G)Ps), that are able to depress the freezing point of body fluids, control the ice crystal nucleation and inhibit their growth. In particular, the latter AFP property, the …