Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Poly(lactide-co-glycolide)"”.
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Investigation of protein destabilization in monodisperse poly(lactide-co-glycolide) microparticles
Poly(lactide-co-glycolide) (PLG) microspheres are a powerful choice for controlled release of protein therapeutics. However, several properties of PLG microspheres, particularly hydrophobicity and acidic microenvironment, may have detrimental effects on encapsulated protein, causing structural …
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Synthesis and Characterization of Injectable Star-shaped Poly(Lactide-co-Glycolide-co-Acrylate) Macromers
<p>Polymers, as hydrogel macromers, have been studied and widely applied to develop scaffolds in tissue engineering since 1990s, because they offer a number of advantages over other materials such as the ability to tailor mechanical properties and degradation kinetics based on various applications. …
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Biophysical characterization of hydrogel-core, lipid-shell nanoparticles (nanolipogels) for HIV chemoprophylaxis
… delivery, providing targeting, protection, and controlled-release capabilities to encapsulated cargo. Polymeric nanoparticles made from poly(lactide-co-glycolide) (PLGA) are biodegradable, exhibit tunable drug release, and have encapsulated a wide variety of biological agents. However, PLGA …
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Fabrication of hydroxyapatite-biodegradable polymer scaffolds by electrospinning for potential bone tissue application
… of this study is to determine the potential of combining hydroxyapatite (HA) and polymers to form synthetic composite materials used for bone tissue engineering applications. In this study, ceramic-biodegradable polymer composites are fabricated by electrospinning method. The biodegradable …
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Chitosan and PLGA microspheres as drug delivery system against pulmonary mycobacteria infections
… of rifampicin (RIF)-loaded microparticles were compared for their stability during nebulization. Poly(lactide-co-glycolide) (PLGA), chitosan (CHT) and PLGA/CHT microparticles (MPs) were prepared by emulsion, precipitation or spray-drying techniques. MPs ability to be nebulized (NE%) as well as …
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Uniform double wall microspheres/microcapsules for protein delivery
Biodegradable polymer devices have been utilized as a means to deliver drugs in a controlled and less invasive manner. Poly (lactide-co-glycolide) (PLG) and poly (lactic acid) (PLA) microparticles such as double-wall/single-wall microspheres and microcapsules were heavily investigated for …
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Development of P(TMC)-Based Polymers for Sustained Delivery of Acid-Sensitive Drugs
Peptides are a quickly growing drug class, which continue to garner attention in pharmaceutical research due to their applications in the treatment of a variety of diseases. The major challenge when working with these drugs is their rapid degradation in vivo and poor membrane-permeability. This …
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Development of a Novel Vaccine Adjuvant System Utilizing an In Situ Implant System to Modified Release
… release and altered immune response, which could act as a booster administration. This type of system was selected because ISI systems are used for long acting administration of various drugs and ease of administration. A typical ISI system is comprised of hydrophilic organic solvent (e.g. …
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Controlled release in inhalation
Increasingly complicated medication regimens associated with the necessity of the repeated dosing of multiple agents used in treating pulmonary disease has been shown to compromise both disease management and patient convenience. In this study the viability of spray drying to introduce controlled …
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Microneedle delivery for improved efficacy of antiretroviral and antibiotic drugs
… of drugs, antiretrovirals and antibiotics, could benefit greatly from delivery through microneedles. Microneedles (MN) offer an increase in efficacy for these drugs by providing delivery to the lymphatic system through the skin, thus avoiding first pass metabolism and allowing more focused …
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The sustained delivery of antisense oligodeoxynucleotides using biodegradable polymer microspheres
Antisense technology is a novel drug discovery method, which provides an essential tool for directly using gene sequence information to rationally design specific inhibitions of mRNA, to treat a wide range of diseases. The efficacy of naked oligodeoxynucleotides (ODNs) is relatively short lived due …
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The Dynamics of Phase Separation and Structure Formation in Phase Inversion
… are presented, the process by which a cast polymer solution is converted into a porous, polymer gel by either thermal or nonsolvent quenching. In all three of the studies presented in this thesis, in-situ optical techniques have been used to study the dynamics of phase separation and …
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A Multicomponent Bioactive Tissue-Engineered Blood Vessel: Fabrication, Mechanical Evaluation and Biological Evaluation with Physiological-Relevant Conditions
… causing adverse hemodynamic, inflammatory or coagulatory events. Current studies focus on developing engineered vascular devices with ability of directing cell activity in vitro and in vivo for tissue regeneration. It is also known that controlled molecule release from scaffolds can …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… from formulation design to routine quality control. Its implementation ensures the consistent quality, performance, and regulatory compliance of medicinal products. For orally administered small-molecule drugs, in vitro testing has been extensively studied to establish a quantitative …
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Functional Self-Assembled Poly (L-Lactide) Nanoparticles For Targeted Delivery of Bioactive Agents
… current treatments present limitations due to costs, side effects, and lack of compatibility. This work will focus on the applications of self-assembled NPs with different functionalities for sustained delivery of growth factors in bone regeneration and targeted delivery of chemotherapeutic …
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Development of supercritical processes for particle coating / encapsulation with polymers
This work presents the investigation of particle coating using supercritical fluid processes as novel coating approaches to coat particles from 20 nanometers to 500 microns with different polymers. Particle coating using different supercritical technologies of a modified rapid expansion of a …
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A Novel Shear Thinning and Thixotropic Plga Micro Particulate Suspension System for Controlled Drug Delivery
<p>Poly lactide‑co‑glycolide (PLGA) polymer has been the polymer of choice for many parenteral controlled drug release applications. This is mainly due to the inherent advantages of this polymer i.e. biodegradability, biocompatibility and non-toxic nature. The polymer, however, has a characteristic …
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Uniform biodegradable microparticle systems for protein delivery
… protein therapeutics’ application. Biodegradable polymer devices have been utilized as a means to deliver drugs in a controlled and less invasive manner. Poly(lactide-co-glycolide) (PLG) and poly(lactic acid) (PLA) microparticles such as double-wall/monolithic microspheres and microcapsules have …
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Synthesis and performance of novel supramolecular tools for single-particle cryogenic electron microscopy and drug and gene delivery
… drug design and basic research into complex biochemical processes. Cryo-EM is an emerging alternative to XRD and NMR that is complementary in many ways relative to XRD and NMR. Materials approaches to cryo-EM are anticipated to greatly facilitate the cryo-EM process, allowing progress …
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Incorporation and release of macromolecules from biodegradable polymer vehicles
… systems with solvent evaporation for the incorporation of a surrogate macromolecule (BSA) into microspheres and microcapsules fabricated using P(HB-HV}, PEA and their blends. Biodegradation, expressed as changes in the gross and ultrastructural morphology of BSA loaded microparticulates with …
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